TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT
TTV is a recently discovered DNA virus, isolated from a patient with post-transfusion hepatitis of unknown etiology by Japanese researchers. In the present study, we evaluated the presence of TTV among chronic liver diseases patients in São Paulo and Pará states, representing two geographically dist...
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Universidade de São Paulo
1998-09-01
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doaj-5e75cfcf3524407d88f0ce311c38c8512020-11-24T22:29:58ZengUniversidade de São PauloRevista do Instituto de Medicina Tropical de São Paulo0036-46651678-99461998-09-0140510.1590/S0036-46651998000500015TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORTJoão R. R. PINHODaniela A. TAKAHASHIAdriano L. B. FAVANeiva S. L. GONÇALESFlair J. CARRILHORaquel S. B STUCCHIFernando L. GONÇALES Jr.Luiz C. DA SILVAManoel C. P. SOARESGilberta BENSABATHGregory A. BUCKGregory A. MEYERSA. Plínio BERNARDINITTV is a recently discovered DNA virus, isolated from a patient with post-transfusion hepatitis of unknown etiology by Japanese researchers. In the present study, we evaluated the presence of TTV among chronic liver diseases patients in São Paulo and Pará states, representing two geographically distinct Brazilian regions. TTV DNA was found in 21/105 (20%) and 9/20 (45%) cases from São Paulo and Pará States, respectively. DNA sequence data confirmed the presence of TTV genotypes 1a and 2a, as well as other genotypes not yet described. In conclusion, TTV is present in chronic liver diseases cases from Southeast and North Brazil. However, further studies involving healthy populations are necessary before establishing any causal relationship among TTV and human hepatitis.<br>TTV é um vírus DNA recentemente descoberto no Japão a partir de um paciente portador de hepatite pós-transfusional de origem desconhecida. Neste estudo, avaliamos a presença deste vírus em pacientes com hepatopatias crônicas dos estados de São Paulo e do Pará, representando duas regiões geograficamente diferentes. O DNA do TTV foi encontrado em 21/105 (20%) e 9/20 (45%) dos casos de São Paulo e do Pará, respectivamente. O seqüenciamento do DNA amplificado confirmou a presença dos genótipos 1a e 2a , bem como de outros genótipos ainda não descritos até o momento. Em conclusão, TTV está presente em casos de hepatopatias crônicas do Sudeste e do Norte do Brasil. Por outro lado, maiores estudos ainda são necessários antes de se estabelecer relação causal entre o TTV e a hepatite em seres humanos.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000500015Hepatitis non A-ETTVViral hepatitisChronic liver diseasesGenotypes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
João R. R. PINHO Daniela A. TAKAHASHI Adriano L. B. FAVA Neiva S. L. GONÇALES Flair J. CARRILHO Raquel S. B STUCCHI Fernando L. GONÇALES Jr. Luiz C. DA SILVA Manoel C. P. SOARES Gilberta BENSABATH Gregory A. BUCK Gregory A. MEYERS A. Plínio BERNARDINI |
spellingShingle |
João R. R. PINHO Daniela A. TAKAHASHI Adriano L. B. FAVA Neiva S. L. GONÇALES Flair J. CARRILHO Raquel S. B STUCCHI Fernando L. GONÇALES Jr. Luiz C. DA SILVA Manoel C. P. SOARES Gilberta BENSABATH Gregory A. BUCK Gregory A. MEYERS A. Plínio BERNARDINI TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT Revista do Instituto de Medicina Tropical de São Paulo Hepatitis non A-E TTV Viral hepatitis Chronic liver diseases Genotypes |
author_facet |
João R. R. PINHO Daniela A. TAKAHASHI Adriano L. B. FAVA Neiva S. L. GONÇALES Flair J. CARRILHO Raquel S. B STUCCHI Fernando L. GONÇALES Jr. Luiz C. DA SILVA Manoel C. P. SOARES Gilberta BENSABATH Gregory A. BUCK Gregory A. MEYERS A. Plínio BERNARDINI |
author_sort |
João R. R. PINHO |
title |
TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT |
title_short |
TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT |
title_full |
TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT |
title_fullStr |
TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT |
title_full_unstemmed |
TRANFUSION-TRANSMITED VIRUS (TTV) IN BRAZIL. PRELIMINARY REPORT |
title_sort |
tranfusion-transmited virus (ttv) in brazil. preliminary report |
publisher |
Universidade de São Paulo |
series |
Revista do Instituto de Medicina Tropical de São Paulo |
issn |
0036-4665 1678-9946 |
publishDate |
1998-09-01 |
description |
TTV is a recently discovered DNA virus, isolated from a patient with post-transfusion hepatitis of unknown etiology by Japanese researchers. In the present study, we evaluated the presence of TTV among chronic liver diseases patients in São Paulo and Pará states, representing two geographically distinct Brazilian regions. TTV DNA was found in 21/105 (20%) and 9/20 (45%) cases from São Paulo and Pará States, respectively. DNA sequence data confirmed the presence of TTV genotypes 1a and 2a, as well as other genotypes not yet described. In conclusion, TTV is present in chronic liver diseases cases from Southeast and North Brazil. However, further studies involving healthy populations are necessary before establishing any causal relationship among TTV and human hepatitis.<br>TTV é um vírus DNA recentemente descoberto no Japão a partir de um paciente portador de hepatite pós-transfusional de origem desconhecida. Neste estudo, avaliamos a presença deste vírus em pacientes com hepatopatias crônicas dos estados de São Paulo e do Pará, representando duas regiões geograficamente diferentes. O DNA do TTV foi encontrado em 21/105 (20%) e 9/20 (45%) dos casos de São Paulo e do Pará, respectivamente. O seqüenciamento do DNA amplificado confirmou a presença dos genótipos 1a e 2a , bem como de outros genótipos ainda não descritos até o momento. Em conclusão, TTV está presente em casos de hepatopatias crônicas do Sudeste e do Norte do Brasil. Por outro lado, maiores estudos ainda são necessários antes de se estabelecer relação causal entre o TTV e a hepatite em seres humanos. |
topic |
Hepatitis non A-E TTV Viral hepatitis Chronic liver diseases Genotypes |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651998000500015 |
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