Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo.

Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo.

Our previous genome-wide linkage analysis identified a susceptibility locus for generalized vitiligo on 22q12. To search for susceptibility genes within the locus, we investigated a biological candidate gene, X-box binding protein 1(XBP1). First, we sequenced all the exons, exon-intron boundaries as...

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Main Authors: Yunqing Ren, Sen Yang, Shengxin Xu, Min Gao, Wei Huang, Tianwen Gao, Qiaoyun Fang, Cheng Quan, Chi Zhang, Liangdan Sun, Yanhua Liang, Jianwen Han, Zhimin Wang, Fengyu Zhang, Youwen Zhou, Jianjun Liu, Xuejun Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2689933?pdf=render

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