Modulation by IL-10 of antigen-induced allergic responses in mice

• Main Authors: Claudia Zuany-Amorim, B Boris Vargaftig, Marina Pretolani
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1997-12-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: interleukin-10; eosinophils; mast cells; TNF-alpha; interleukin-5
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800019

Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC). We showed that IL-10, concurrently administered with ovalbumin, inhibited inflammatory cell accumulation in the airways and in the peritoneal cavity of sensitized mice, as well as the accompanying cytokine release. IL-10 also blocked antigen-induced cytokine generation by IgE-stimulated BMMC. Together, these results identify a novel biological property of IL-10, as a cytokine with potent anti-allergic activities.