Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-st...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21931-9 |
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doaj-5e96ad72a7fc4e428e30cd13deb2825b2021-03-21T12:14:51ZengNature Publishing GroupNature Communications2041-17232021-03-0112111410.1038/s41467-021-21931-9Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fractionGabriele G. Schiattarella0Francisco Altamirano1Soo Young Kim2Dan Tong3Anwarul Ferdous4Hande Piristine5Subhajit Dasgupta6Xuliang Wang7Kristin M. French8Elisa Villalobos9Stephen B. Spurgin10Maayan Waldman11Nan Jiang12Herman I. May13Theodore M. Hill14Yuxuan Luo15Heesoo Yoo16Vlad G. Zaha17Sergio Lavandero18Thomas G. Gillette19Joseph A. Hill20Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Pediatrics, University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical CenterHeart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes.https://doi.org/10.1038/s41467-021-21931-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gabriele G. Schiattarella Francisco Altamirano Soo Young Kim Dan Tong Anwarul Ferdous Hande Piristine Subhajit Dasgupta Xuliang Wang Kristin M. French Elisa Villalobos Stephen B. Spurgin Maayan Waldman Nan Jiang Herman I. May Theodore M. Hill Yuxuan Luo Heesoo Yoo Vlad G. Zaha Sergio Lavandero Thomas G. Gillette Joseph A. Hill |
| spellingShingle |
Gabriele G. Schiattarella Francisco Altamirano Soo Young Kim Dan Tong Anwarul Ferdous Hande Piristine Subhajit Dasgupta Xuliang Wang Kristin M. French Elisa Villalobos Stephen B. Spurgin Maayan Waldman Nan Jiang Herman I. May Theodore M. Hill Yuxuan Luo Heesoo Yoo Vlad G. Zaha Sergio Lavandero Thomas G. Gillette Joseph A. Hill Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction Nature Communications |
| author_facet |
Gabriele G. Schiattarella Francisco Altamirano Soo Young Kim Dan Tong Anwarul Ferdous Hande Piristine Subhajit Dasgupta Xuliang Wang Kristin M. French Elisa Villalobos Stephen B. Spurgin Maayan Waldman Nan Jiang Herman I. May Theodore M. Hill Yuxuan Luo Heesoo Yoo Vlad G. Zaha Sergio Lavandero Thomas G. Gillette Joseph A. Hill |
| author_sort |
Gabriele G. Schiattarella |
| title |
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| title_short |
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| title_full |
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| title_fullStr |
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| title_full_unstemmed |
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| title_sort |
xbp1s-foxo1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
Heart failure with preserved ejection fraction (HFpEF) is a global, major health issue for which no effective therapies are available. Here, the authors discover that the interplay between two transcription factors, Xbp1s and FoxO1, is critical for metabolic adaptation and lipid handling in HFpEF-stressed cardiomyocytes. |
| url |
https://doi.org/10.1038/s41467-021-21931-9 |
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