The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia
Objective: To evaluate the use of serum level of dehydroepiandrosteronesulfate as a screening test for late-onset congenital adrenal hyperplasia.Methods: Fourteen hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate, 17 hirsute women with normal serumlevels of dehydroepiandroste...
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2006-06-01
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doaj-5e99b4c7be484a9db518770b187ae4ab2020-11-24T23:00:43ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)1679-45082006-06-014295100The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasiaMarcos Yorghi KhouryEdmund Chada BaracatDolores Perovano PardiniRita de Cássia CastroOdilon Victor Porto DenardinGeraldo Rodrigues de LimaObjective: To evaluate the use of serum level of dehydroepiandrosteronesulfate as a screening test for late-onset congenital adrenal hyperplasia.Methods: Fourteen hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate, 17 hirsute women with normal serumlevels of dehydroepiandrosterone sulfate, and 12 non-hirsute ovulatorywomen were selected. Blood samples were collected before and 1hour after the adrenocorticotropic hormone stimulation test. Serumlevels of dehydroepiandrosterone sulfate were measured before theadrenocorticotropic hormone stimulation test. Serum levels of 17-hydroxyprogesterone, compound S, 17-hydroxypregnenolone,dehydroepiandrosterone, androstenedione, and cortisol weremeasured 1 hour after the adrenocorticotropic hormone stimulationtest. Results: Two hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate satisfied the criterion for late-onsetcongenital adrenal hyperplasia due to 21-hydroxylase deficiency, i.e.,a serum level of 17-hydroxyprogesterone after the adrenocorticotropichormone stimulation test >1000 ng/dL. No hirsute woman had 11bhydroxylaseor 3b-hydroxysteroid dehydrogenase deficiency.Conclusions: Serum level of dehydroepiandrosterone sulfate is usefulas a screening test for late-onset congenital adrenal hyperplasia. Anelevated serum level of dehydroepiandrosterone sulfate does notnecessarily mean an adrenal enzymatic defect, whereas a normalvalue excludes the possibility of late-onset congenital adrenalhyperplasia.http://www.einstein.br/revista/arquivos/PDF/Einstein%20vol4%20n2_95.pdfAdrenal hyperplasiacongenitalDehydroepiandrosteroneHirsutismSteroid 21-hydroxylaseSteroid 11-beta-hydroxylase3-Hydroxysteroid dehydrogenases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcos Yorghi Khoury Edmund Chada Baracat Dolores Perovano Pardini Rita de Cássia Castro Odilon Victor Porto Denardin Geraldo Rodrigues de Lima |
spellingShingle |
Marcos Yorghi Khoury Edmund Chada Baracat Dolores Perovano Pardini Rita de Cássia Castro Odilon Victor Porto Denardin Geraldo Rodrigues de Lima The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia Einstein (São Paulo) Adrenal hyperplasia congenital Dehydroepiandrosterone Hirsutism Steroid 21-hydroxylase Steroid 11-beta-hydroxylase 3-Hydroxysteroid dehydrogenases |
author_facet |
Marcos Yorghi Khoury Edmund Chada Baracat Dolores Perovano Pardini Rita de Cássia Castro Odilon Victor Porto Denardin Geraldo Rodrigues de Lima |
author_sort |
Marcos Yorghi Khoury |
title |
The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
title_short |
The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
title_full |
The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
title_fullStr |
The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
title_full_unstemmed |
The value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
title_sort |
value of serum levels of dehydroepiandrosterone sulfate as a screening test for late-onset congenital adrenal hyperplasia |
publisher |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
series |
Einstein (São Paulo) |
issn |
1679-4508 |
publishDate |
2006-06-01 |
description |
Objective: To evaluate the use of serum level of dehydroepiandrosteronesulfate as a screening test for late-onset congenital adrenal hyperplasia.Methods: Fourteen hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate, 17 hirsute women with normal serumlevels of dehydroepiandrosterone sulfate, and 12 non-hirsute ovulatorywomen were selected. Blood samples were collected before and 1hour after the adrenocorticotropic hormone stimulation test. Serumlevels of dehydroepiandrosterone sulfate were measured before theadrenocorticotropic hormone stimulation test. Serum levels of 17-hydroxyprogesterone, compound S, 17-hydroxypregnenolone,dehydroepiandrosterone, androstenedione, and cortisol weremeasured 1 hour after the adrenocorticotropic hormone stimulationtest. Results: Two hirsute women with elevated serum levels ofdehydroepiandrosterone sulfate satisfied the criterion for late-onsetcongenital adrenal hyperplasia due to 21-hydroxylase deficiency, i.e.,a serum level of 17-hydroxyprogesterone after the adrenocorticotropichormone stimulation test >1000 ng/dL. No hirsute woman had 11bhydroxylaseor 3b-hydroxysteroid dehydrogenase deficiency.Conclusions: Serum level of dehydroepiandrosterone sulfate is usefulas a screening test for late-onset congenital adrenal hyperplasia. Anelevated serum level of dehydroepiandrosterone sulfate does notnecessarily mean an adrenal enzymatic defect, whereas a normalvalue excludes the possibility of late-onset congenital adrenalhyperplasia. |
topic |
Adrenal hyperplasia congenital Dehydroepiandrosterone Hirsutism Steroid 21-hydroxylase Steroid 11-beta-hydroxylase 3-Hydroxysteroid dehydrogenases |
url |
http://www.einstein.br/revista/arquivos/PDF/Einstein%20vol4%20n2_95.pdf |
work_keys_str_mv |
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