Sec16 alternative splicing dynamically controls COPII transport efficiency

The transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T cell activation.

Bibliographic Details
Main Authors:	Ilka Wilhelmi, Regina Kanski, Alexander Neumann, Olga Herdt, Florian Hoff, Ralf Jacob, Marco Preußner, Florian Heyd
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12347

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spelling	doaj-5eac4601c94e4e0ea0fcc66ec338cff32021-05-11T11:07:29ZengNature Publishing GroupNature Communications2041-17232016-08-017111410.1038/ncomms12347Sec16 alternative splicing dynamically controls COPII transport efficiencyIlka Wilhelmi0Regina Kanski1Alexander Neumann2Olga Herdt3Florian Hoff4Ralf Jacob5Marco Preußner6Florian Heyd7Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryDepartment of Cell Biology and Cell Pathology, Philipps-University MarburgDepartment of Cell Biology and Cell Pathology, Philipps-University MarburgDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryDepartment of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Institute of Chemistry and Biochemistry, Laboratory of RNA BiochemistryThe transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T cell activation.https://doi.org/10.1038/ncomms12347
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ilka Wilhelmi Regina Kanski Alexander Neumann Olga Herdt Florian Hoff Ralf Jacob Marco Preußner Florian Heyd
spellingShingle	Ilka Wilhelmi Regina Kanski Alexander Neumann Olga Herdt Florian Hoff Ralf Jacob Marco Preußner Florian Heyd Sec16 alternative splicing dynamically controls COPII transport efficiency Nature Communications
author_facet	Ilka Wilhelmi Regina Kanski Alexander Neumann Olga Herdt Florian Hoff Ralf Jacob Marco Preußner Florian Heyd
author_sort	Ilka Wilhelmi
title	Sec16 alternative splicing dynamically controls COPII transport efficiency
title_short	Sec16 alternative splicing dynamically controls COPII transport efficiency
title_full	Sec16 alternative splicing dynamically controls COPII transport efficiency
title_fullStr	Sec16 alternative splicing dynamically controls COPII transport efficiency
title_full_unstemmed	Sec16 alternative splicing dynamically controls COPII transport efficiency
title_sort	sec16 alternative splicing dynamically controls copii transport efficiency
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	The transport of secretory proteins from the endoplasmic reticulum to the Golgi depends on COPII-coated vesicles. Here, the authors show that activation-induced alternative splicing of Sec16 controls adaptation of COPII transport to increased secretory cargo upon T cell activation.
url	https://doi.org/10.1038/ncomms12347
work_keys_str_mv	AT ilkawilhelmi sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT reginakanski sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT alexanderneumann sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT olgaherdt sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT florianhoff sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT ralfjacob sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT marcopreußner sec16alternativesplicingdynamicallycontrolscopiitransportefficiency AT florianheyd sec16alternativesplicingdynamicallycontrolscopiitransportefficiency
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Sec16 alternative splicing dynamically controls COPII transport efficiency

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