IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL
Abstract Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating prot...
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doaj-5ebfd112aa7d490aa9eda628015d80bd2021-05-30T11:49:02ZengBMCBMC Cancer1471-24072021-05-0121111110.1186/s12885-021-08086-yIQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCLTianjiao Tang0Jing Wang1Lidan Zhang2Ying Cheng3Laura Saleh4Yanni Gu5Hongbin Zhang6Department of Hematology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Hematology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Hematology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Hematology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurosurgery, Johns Hopkins University School of MedicineDepartment of Neuroscience, Johns Hopkins UniversityDepartment of Hematology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. Methods We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. Results The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. Conclusion IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy.https://doi.org/10.1186/s12885-021-08086-yDLBCLIQGAP2ImmunosuppressionPrognostic factorIndependent factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tianjiao Tang Jing Wang Lidan Zhang Ying Cheng Laura Saleh Yanni Gu Hongbin Zhang |
spellingShingle |
Tianjiao Tang Jing Wang Lidan Zhang Ying Cheng Laura Saleh Yanni Gu Hongbin Zhang IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL BMC Cancer DLBCL IQGAP2 Immunosuppression Prognostic factor Independent factor |
author_facet |
Tianjiao Tang Jing Wang Lidan Zhang Ying Cheng Laura Saleh Yanni Gu Hongbin Zhang |
author_sort |
Tianjiao Tang |
title |
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_short |
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_full |
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_fullStr |
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_full_unstemmed |
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL |
title_sort |
iqgap2 acts as an independent prognostic factor and is related to immunosuppression in dlbcl |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2021-05-01 |
description |
Abstract Background Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will provide therapeutic targets. IQ motif-containing GTPase activating protein 2 (IQGAP2) acts as a tumour suppressor in hepatocellular, prostate, and gastric cancers. However, the role of IQGAP2 in DLBCL remains unclear. Methods We collected mRNA expression data from 614 samples and the corresponding clinical information. The survival time of patients was compared between groups according to the mRNA expression level of IQGAP2. Survival analyses were performed in different subgroups when considering the effect of age, tumour stage, serum lactate dehydrogenase (LDH) concentration, performance status, and the number of extra nodal disease sites. The biological processes associated with IQGAP2-associated mRNAs were analysed to predict the function of IQGAP2. The correlation of IQGAP2 mRNA with immunosuppressive genes and leukocyte infiltration were analysed. Results The overall survival of patients with increased IQGAP2 mRNA levels was reduced even after aggressive treatment independent of age, tumour stage, serum LDH concentration, performance status, and the number of extra nodal disease sites. Furthermore, the biological processes of IQGAP2-associated mRNAs were mainly immune processes. IQGAP2 mRNA expression was correlated with the expression of immunosuppressive genes and leukocyte infiltration. Conclusion IQGAP2 mRNA is an independent prognostic factor and is related to immunosuppression in DLBCL. This discovery may provide a promising target for further development of therapy. |
topic |
DLBCL IQGAP2 Immunosuppression Prognostic factor Independent factor |
url |
https://doi.org/10.1186/s12885-021-08086-y |
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