Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients
Background: A growing body of evidence is emerging suggesting testosterone can affect all cells involved in the immune response to both bacterial and viral infections, and the testosterone effect on the immune response could explain the greater susceptibility of men to infections including COVID-19....
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doaj-5ec1dae10dce4dc59d461ca84b21d6502021-03-25T00:02:40ZengMDPI AGDiagnostics2075-44182021-03-011158158110.3390/diagnostics11040581Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 PatientsStefano Salciccia0Michael L. Eisenberg1Martina Maggi2Silvia Lai3Claudio Maria Mastroianni4Patrizia Pasculli5Maria Rosa Ciardi6Vittorio Canale7Matteo Ferro8Gian Maria Busetto9Ettore De Berardinis10Gian Piero Ricciuti11Alessandro Sciarra12Francesco Del Giudice13Department of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Translational and Precision Medicine, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Urology, European Institute of Oncology (IEO), IRCCS, 20141 Milan, ItalyDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyDepartment of Maternal-Infant and Urological Sciences, “Sapienza” University of Rome, Policlinico Umberto I Hospital, 00161 Rome, ItalyBackground: A growing body of evidence is emerging suggesting testosterone can affect all cells involved in the immune response to both bacterial and viral infections, and the testosterone effect on the immune response could explain the greater susceptibility of men to infections including COVID-19. We aimed to explore the predictive role of male serum total testosterone (TT) levels on the time till viral negativity testing among hospitalized COVID-19 patients. <b>Methods:</b> The univariate effect of risk factors for the duration of COVID-19 viral positivity was evaluated using the log-rank test and Kaplan–Meier estimates. A multivariable Cox regression model was developed to test the role of TT levels and the subsequent odds for shorter viral positivity intervals. <b>Results:</b> Increasing serum TT levels and the need for an oxygen administration strategy were independently predictive for respectively reduced and increased days to negativization (Hazard Ratio [HR]: 1.39, 95% CI: 0.95–2.03 and HR: 0.19, 95% CI: 0.03–1.18). <b>Conclusion:</b> Baseline higher TT levels for male COVID-19 patients at hospital admission are associated with shorter durations of positive COVID-19 testing and thus viral clearance. Our preliminary findings might play a relevant to help pandemic control strategies if these will be verified in future larger multicentric and possibly randomized trials.https://www.mdpi.com/2075-4418/11/4/581COVID-19total testosteronemale serum testosteroneviral positivity durationCOVID-19 testing |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefano Salciccia Michael L. Eisenberg Martina Maggi Silvia Lai Claudio Maria Mastroianni Patrizia Pasculli Maria Rosa Ciardi Vittorio Canale Matteo Ferro Gian Maria Busetto Ettore De Berardinis Gian Piero Ricciuti Alessandro Sciarra Francesco Del Giudice |
spellingShingle |
Stefano Salciccia Michael L. Eisenberg Martina Maggi Silvia Lai Claudio Maria Mastroianni Patrizia Pasculli Maria Rosa Ciardi Vittorio Canale Matteo Ferro Gian Maria Busetto Ettore De Berardinis Gian Piero Ricciuti Alessandro Sciarra Francesco Del Giudice Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients Diagnostics COVID-19 total testosterone male serum testosterone viral positivity duration COVID-19 testing |
author_facet |
Stefano Salciccia Michael L. Eisenberg Martina Maggi Silvia Lai Claudio Maria Mastroianni Patrizia Pasculli Maria Rosa Ciardi Vittorio Canale Matteo Ferro Gian Maria Busetto Ettore De Berardinis Gian Piero Ricciuti Alessandro Sciarra Francesco Del Giudice |
author_sort |
Stefano Salciccia |
title |
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients |
title_short |
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients |
title_full |
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients |
title_fullStr |
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients |
title_full_unstemmed |
Modeling the Contribution of Male Testosterone Levels to the Duration of Positive COVID Testing among Hospitalized Male COVID-19 Patients |
title_sort |
modeling the contribution of male testosterone levels to the duration of positive covid testing among hospitalized male covid-19 patients |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2021-03-01 |
description |
Background: A growing body of evidence is emerging suggesting testosterone can affect all cells involved in the immune response to both bacterial and viral infections, and the testosterone effect on the immune response could explain the greater susceptibility of men to infections including COVID-19. We aimed to explore the predictive role of male serum total testosterone (TT) levels on the time till viral negativity testing among hospitalized COVID-19 patients. <b>Methods:</b> The univariate effect of risk factors for the duration of COVID-19 viral positivity was evaluated using the log-rank test and Kaplan–Meier estimates. A multivariable Cox regression model was developed to test the role of TT levels and the subsequent odds for shorter viral positivity intervals. <b>Results:</b> Increasing serum TT levels and the need for an oxygen administration strategy were independently predictive for respectively reduced and increased days to negativization (Hazard Ratio [HR]: 1.39, 95% CI: 0.95–2.03 and HR: 0.19, 95% CI: 0.03–1.18). <b>Conclusion:</b> Baseline higher TT levels for male COVID-19 patients at hospital admission are associated with shorter durations of positive COVID-19 testing and thus viral clearance. Our preliminary findings might play a relevant to help pandemic control strategies if these will be verified in future larger multicentric and possibly randomized trials. |
topic |
COVID-19 total testosterone male serum testosterone viral positivity duration COVID-19 testing |
url |
https://www.mdpi.com/2075-4418/11/4/581 |
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