Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid
Cellular membranes are composed of thousands of different lipids usually maintained within a narrow range of concentrations. In addition to their well-known structural and metabolic roles, signaling functions for many lipids have also emerged over the last two decades. The latter largely depend on t...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-04-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | http://www.mdpi.com/2218-273X/8/2/20 |
id |
doaj-5ec25f6c01164b27b23a439626929ba7 |
---|---|
record_format |
Article |
spelling |
doaj-5ec25f6c01164b27b23a439626929ba72020-11-24T21:04:13ZengMDPI AGBiomolecules2218-273X2018-04-01822010.3390/biom8020020biom8020020Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic AcidEmeline Tanguy0Nawal Kassas1Nicolas Vitale2Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR3212 and Université de Strasbourg, 67000 Strasbourg, FranceInstitut des Neurosciences Cellulaires et Intégratives, CNRS UPR3212 and Université de Strasbourg, 67000 Strasbourg, FranceInstitut des Neurosciences Cellulaires et Intégratives, CNRS UPR3212 and Université de Strasbourg, 67000 Strasbourg, FranceCellular membranes are composed of thousands of different lipids usually maintained within a narrow range of concentrations. In addition to their well-known structural and metabolic roles, signaling functions for many lipids have also emerged over the last two decades. The latter largely depend on the ability of particular classes of lipids to interact specifically with a great variety of proteins and to regulate their localization and activity. Among these lipids, phosphatidic acid (PA) plays a unique role in a large repertoire of cellular activities, most likely in relation to its unique biophysical properties. However, until recently, only incomplete information was available to model the interaction between PA and its protein partners. The development of new liposome-based assays as well as molecular dynamic simulation are now providing novel information. We will review the different factors that have shown to modulate the capacity of PA to interact with specific domains in target proteins.http://www.mdpi.com/2218-273X/8/2/20interaction motiflipid bindingmembranephospholipase Dphosphatidic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emeline Tanguy Nawal Kassas Nicolas Vitale |
spellingShingle |
Emeline Tanguy Nawal Kassas Nicolas Vitale Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid Biomolecules interaction motif lipid binding membrane phospholipase D phosphatidic acid |
author_facet |
Emeline Tanguy Nawal Kassas Nicolas Vitale |
author_sort |
Emeline Tanguy |
title |
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid |
title_short |
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid |
title_full |
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid |
title_fullStr |
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid |
title_full_unstemmed |
Protein–Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid |
title_sort |
protein–phospholipid interaction motifs: a focus on phosphatidic acid |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2018-04-01 |
description |
Cellular membranes are composed of thousands of different lipids usually maintained within a narrow range of concentrations. In addition to their well-known structural and metabolic roles, signaling functions for many lipids have also emerged over the last two decades. The latter largely depend on the ability of particular classes of lipids to interact specifically with a great variety of proteins and to regulate their localization and activity. Among these lipids, phosphatidic acid (PA) plays a unique role in a large repertoire of cellular activities, most likely in relation to its unique biophysical properties. However, until recently, only incomplete information was available to model the interaction between PA and its protein partners. The development of new liposome-based assays as well as molecular dynamic simulation are now providing novel information. We will review the different factors that have shown to modulate the capacity of PA to interact with specific domains in target proteins. |
topic |
interaction motif lipid binding membrane phospholipase D phosphatidic acid |
url |
http://www.mdpi.com/2218-273X/8/2/20 |
work_keys_str_mv |
AT emelinetanguy proteinphospholipidinteractionmotifsafocusonphosphatidicacid AT nawalkassas proteinphospholipidinteractionmotifsafocusonphosphatidicacid AT nicolasvitale proteinphospholipidinteractionmotifsafocusonphosphatidicacid |
_version_ |
1716771513975177216 |