Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

The first total synthesis of the marine bromotyrosine purpurealidin I (<b>1</b>) using trifluoroacetoxy protection group and its dimethylated analog (<b>29</b>) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was...

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Bibliographic Details
Main Authors:	Chinmay Bhat, Polina Ilina, Irene Tilli, Manuela Voráčová, Tanja Bruun, Victoria Barba, Nives Hribernik, Katja-Emilia Lillsunde, Eero Mäki-Lohiluoma, Tobias Rüffer, Heinrich Lang, Jari Yli-Kauhaluoma, Paula Kiuru, Päivi Tammela
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Marine Drugs
Subjects:	Purpurealidin I bromotyrosines <i>Pseudoceratina purpurea</i> synthesis cytotoxicity selectivity to cancer cells
Online Access:	https://www.mdpi.com/1660-3397/16/12/481

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