Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis
Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract,...
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doaj-5ec446c896e9446ba774ad2aff5bdb2d2020-11-24T21:23:43ZengMDPI AGMolecules1420-30492014-12-011912209062091210.3390/molecules191220906molecules191220906Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidisLi-Wei He0Hua-Qing Liu1Yu-Qing Chen2Jing-Yan Yang3Tian-Lin Wang4Wei Li5School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, ChinaThe Second Hospital of Nanjing, 1-1 ZhongFu Road, Nanjing 210003, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, ChinaRadix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development.http://www.mdpi.com/1420-3049/19/12/20906Radix isatidisisoquinoline derivativeanti-viral activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Wei He Hua-Qing Liu Yu-Qing Chen Jing-Yan Yang Tian-Lin Wang Wei Li |
spellingShingle |
Li-Wei He Hua-Qing Liu Yu-Qing Chen Jing-Yan Yang Tian-Lin Wang Wei Li Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis Molecules Radix isatidis isoquinoline derivative anti-viral activity |
author_facet |
Li-Wei He Hua-Qing Liu Yu-Qing Chen Jing-Yan Yang Tian-Lin Wang Wei Li |
author_sort |
Li-Wei He |
title |
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis |
title_short |
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis |
title_full |
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis |
title_fullStr |
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis |
title_full_unstemmed |
Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis |
title_sort |
total synthesis and anti-viral activities of an extract of radix isatidis |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-12-01 |
description |
Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. |
topic |
Radix isatidis isoquinoline derivative anti-viral activity |
url |
http://www.mdpi.com/1420-3049/19/12/20906 |
work_keys_str_mv |
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