An Enflammatory Marker in Chronic Renal Failure Patients: Visfatin

• Main Authors: Yavuz Ayar, Çiğdem Aksu, Fatih Pektaş
• Format: Article
• Language: English
• Published: Galenos Yayinevi 2010-12-01
• Series: Haseki Tıp Bülteni
• Subjects: Chronic renal failure; visfatin; enflammation
• Online Access: http://www.hasekidergisi.com/makale_9698/Kronik-Bobrek-Yetmezligi-Hastalarinda-Enflamatuvar-Bir-Belirtec-Visfatin

Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker. Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludağ University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined. Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker. Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation. (The Medical Bulletin of Haseki 2013; 53: 187-91)