Clinical Genetics of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic components. There are two major types of AD, early onset and the more common late onset. The genetics of earl...
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Online Access: | http://dx.doi.org/10.1155/2014/291862 |
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doaj-5ed509e796ff49849f14622c2d60af1e2020-11-25T01:03:08ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/291862291862Clinical Genetics of Alzheimer’s DiseaseZhangyu Zou0Changyun Liu1Chunhui Che2Huapin Huang3Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaDepartment of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, ChinaAlzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic components. There are two major types of AD, early onset and the more common late onset. The genetics of early-onset AD are largely understood with mutations in three different genes leading to the disease. In contrast, while susceptibility loci and alleles associated with late-onset AD have been identified using genetic association studies, the genetics of late-onset Alzheimer’s disease are not fully understood. Here we review the known genetics of early- and late-onset AD, the clinical features of EOAD according to genotypes, and the clinical implications of the genetics of AD.http://dx.doi.org/10.1155/2014/291862 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhangyu Zou Changyun Liu Chunhui Che Huapin Huang |
spellingShingle |
Zhangyu Zou Changyun Liu Chunhui Che Huapin Huang Clinical Genetics of Alzheimer’s Disease BioMed Research International |
author_facet |
Zhangyu Zou Changyun Liu Chunhui Che Huapin Huang |
author_sort |
Zhangyu Zou |
title |
Clinical Genetics of Alzheimer’s Disease |
title_short |
Clinical Genetics of Alzheimer’s Disease |
title_full |
Clinical Genetics of Alzheimer’s Disease |
title_fullStr |
Clinical Genetics of Alzheimer’s Disease |
title_full_unstemmed |
Clinical Genetics of Alzheimer’s Disease |
title_sort |
clinical genetics of alzheimer’s disease |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic components. There are two major types of AD, early onset and the more common late onset. The genetics of early-onset AD are largely understood with mutations in three different genes leading to the disease. In contrast, while susceptibility loci and alleles associated with late-onset AD have been identified using genetic association studies, the genetics of late-onset Alzheimer’s disease are not fully understood. Here we review the known genetics of early- and late-onset AD, the clinical features of EOAD according to genotypes, and the clinical implications of the genetics of AD. |
url |
http://dx.doi.org/10.1155/2014/291862 |
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