Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma
Abstract Background Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and...
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doaj-5ed8f6f70e91457d87cefe33bf6e50262020-11-25T04:08:12ZengBMCLipids in Health and Disease1476-511X2020-10-011911910.1186/s12944-020-01390-9Lipid metabolism gene-wide profile and survival signature of lung adenocarcinomaJinyou Li0Qiang Li1Zhenyu Su2Qi Sun3Yong Zhao4Tienan Feng5Jiayuan Jiang6Feng Zhang7Haitao Ma8Department of Thoracic Surgery, Affiliated Hospital of Jiangnan UniversityPublic Health School, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Affiliated Hospital of Jiangnan UniversityDepartment of Thoracic Surgery, Affiliated Hospital of Jiangnan UniversityDepartment of Thoracic Surgery, Affiliated Hospital of Jiangnan UniversityClinical Research Institute, Shanghai Jiao Tong University School of MedicineClinical Research Institute, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Affiliated Hospital of Jiangnan UniversityDepartment of Thoracic Surgery, First Affiliated Hospital of Soochow UniversityAbstract Background Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD. Methods In this study, expression analysis of 1045 lipid metabolism-related genes was performed between LUAD tumors and normal tissues derived from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) cohort. The interaction network of differentially expressed genes (DEGs) was constructed to identify the hub genes. The association between hub genes and overall survival (OS) was evaluated and formed a model to predict the prognosis of LUAD using a nomogram. The model was validated by another cohort, GSE13213. Results A total of 217 lipid metabolism-related DEGs were detected in LUAD. Genes were significantly enriched in glycerophospholipid metabolism, fatty acid metabolic process, and eicosanoid signaling. Through network analysis and cytoHubba, 6 hub genes were identified, including INS, LPL, HPGDS, DGAT1, UGT1A6, and CYP2C9. High expression of CYP2C9, UGT1A6, and INS, and low expressions of DGAT1, HPGDS, and LPL, were associated with worse overall survival for 1925 LUAD patients. The model showed that the high-risk score group had a worse OS, and the validated cohort showed the same result. Conclusions In this study, a signature of 6 lipid metabolism genes was constructed, which was significantly associated with the diagnosis and prognosis of LUAD patients. Thus, the gene signature can be used as a biomarker for LUAD.http://link.springer.com/article/10.1186/s12944-020-01390-9DiagnosisHub genesLipid metabolismLung adenocarcinomaNomogramPrognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinyou Li Qiang Li Zhenyu Su Qi Sun Yong Zhao Tienan Feng Jiayuan Jiang Feng Zhang Haitao Ma |
spellingShingle |
Jinyou Li Qiang Li Zhenyu Su Qi Sun Yong Zhao Tienan Feng Jiayuan Jiang Feng Zhang Haitao Ma Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma Lipids in Health and Disease Diagnosis Hub genes Lipid metabolism Lung adenocarcinoma Nomogram Prognosis |
author_facet |
Jinyou Li Qiang Li Zhenyu Su Qi Sun Yong Zhao Tienan Feng Jiayuan Jiang Feng Zhang Haitao Ma |
author_sort |
Jinyou Li |
title |
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
title_short |
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
title_full |
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
title_fullStr |
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
title_full_unstemmed |
Lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
title_sort |
lipid metabolism gene-wide profile and survival signature of lung adenocarcinoma |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2020-10-01 |
description |
Abstract Background Lung cancer has high morbidity and mortality across the globe, and lung adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid metabolism is related to the development of cancer. Analysis of lipid-related transcriptome helps shed light on the diagnosis and prognostic biomarkers of LUAD. Methods In this study, expression analysis of 1045 lipid metabolism-related genes was performed between LUAD tumors and normal tissues derived from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) cohort. The interaction network of differentially expressed genes (DEGs) was constructed to identify the hub genes. The association between hub genes and overall survival (OS) was evaluated and formed a model to predict the prognosis of LUAD using a nomogram. The model was validated by another cohort, GSE13213. Results A total of 217 lipid metabolism-related DEGs were detected in LUAD. Genes were significantly enriched in glycerophospholipid metabolism, fatty acid metabolic process, and eicosanoid signaling. Through network analysis and cytoHubba, 6 hub genes were identified, including INS, LPL, HPGDS, DGAT1, UGT1A6, and CYP2C9. High expression of CYP2C9, UGT1A6, and INS, and low expressions of DGAT1, HPGDS, and LPL, were associated with worse overall survival for 1925 LUAD patients. The model showed that the high-risk score group had a worse OS, and the validated cohort showed the same result. Conclusions In this study, a signature of 6 lipid metabolism genes was constructed, which was significantly associated with the diagnosis and prognosis of LUAD patients. Thus, the gene signature can be used as a biomarker for LUAD. |
topic |
Diagnosis Hub genes Lipid metabolism Lung adenocarcinoma Nomogram Prognosis |
url |
http://link.springer.com/article/10.1186/s12944-020-01390-9 |
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