Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles
<p>Background. While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation and gamma knife thalamotomy. The mos...
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doaj-5ee4b20c74914c02a6eee56da82d093c2021-04-02T09:25:54ZengUbiquity PressTremor and Other Hyperkinetic Movements2160-82882017-05-01710.7916/D8Z89JN1319Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current HurdlesMohammad Rohani0Alfonso Fasano1Department of Neurology, Hazrat Rasool Hospital, Iran University of Medical SciencesUniversity of Toronto, Toronto<p>Background. While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS).</p> <p>Methods. Purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders.</p> <p>Results. MRgFUS is an incision-less surgery performed without anesthesia and ionizing radiation (no risk of cumulative dose and delayed side effects). Studies have shown the safety and effectiveness of unilateral MRgFUS-thalamotomy in the treatment of ET. It has been successfully used in few patients with Parkinson's disease-related tremor and fewer patients with Fragile X-associated Tremor/Ataxia Syndrome. Safety and long-term effects of the procedure are still unclear, as temporary and permanent adverse events have been reported as well as reoccurrence of tremor.</p> <p>Discussion. MRgFUS is a promising new surgical approach with still a number of unknowns and unsolved issues. It represents a valuable option particularly for patients who refused or could not be candidate for other procedures, deep brain stimulation in particular. </p>https://tremorjournal.org/index.php/tremor/article/view/462 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Rohani Alfonso Fasano |
spellingShingle |
Mohammad Rohani Alfonso Fasano Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles Tremor and Other Hyperkinetic Movements |
author_facet |
Mohammad Rohani Alfonso Fasano |
author_sort |
Mohammad Rohani |
title |
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles |
title_short |
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles |
title_full |
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles |
title_fullStr |
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles |
title_full_unstemmed |
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles |
title_sort |
focused ultrasound for essential tremor: review of the evidence and discussion of current hurdles |
publisher |
Ubiquity Press |
series |
Tremor and Other Hyperkinetic Movements |
issn |
2160-8288 |
publishDate |
2017-05-01 |
description |
<p>Background. While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS).</p> <p>Methods. Purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders.</p> <p>Results. MRgFUS is an incision-less surgery performed without anesthesia and ionizing radiation (no risk of cumulative dose and delayed side effects). Studies have shown the safety and effectiveness of unilateral MRgFUS-thalamotomy in the treatment of ET. It has been successfully used in few patients with Parkinson's disease-related tremor and fewer patients with Fragile X-associated Tremor/Ataxia Syndrome. Safety and long-term effects of the procedure are still unclear, as temporary and permanent adverse events have been reported as well as reoccurrence of tremor.</p> <p>Discussion. MRgFUS is a promising new surgical approach with still a number of unknowns and unsolved issues. It represents a valuable option particularly for patients who refused or could not be candidate for other procedures, deep brain stimulation in particular. </p> |
url |
https://tremorjournal.org/index.php/tremor/article/view/462 |
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