Pattern of Haemoglobin Disorders

• Main Author: Samina Amanat
• Format: Article
• Language: English
• Published: Rawalpindi Medical University 2012-06-01
• Series: Journal of Rawalpindi Medical College
• Subjects: Haemoglobin disorders; Haemoglobin electrophoresis; Thalassaemia
• Online Access: https://www.journalrmc.com/index.php/JRMC/article/view/598

Background: To study the pattern of different haemoglobin disorders in our set up. Methods: In this descriptive study, patients referred for haemoglobin electrophoresis were included. Detailed clinical history was taken. Physical findings were noted. Peripheral blood film and haemoglobin electrophoresis was performed . Results: Out of total 666 referred cases , 176 (26.4%) were detected to have abnormal haemoglobin. The commonest disorder was beta thalassaemia trait (13.2%). Beta thalassaemia major was found in 9.9 % cases. Other haemoglobin disorders like HbD,HbE, and HbS alone or in combination with beta thalassaemia were detected in 2.95% cases. One case of beta thalassaemia minor revealed normal pattern on haemoglobin electrophoresis and was diagnosed on molecular studies Conclusion: The increased trend of haemoglobin electrophoresis employment predicts a decline in homozygous states of autosomal recessive haemoglobin disorders