Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation
Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.
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Nature Publishing Group
2017-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14265 |
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doaj-5ef612302b2040f09104c825b57b21162021-05-11T07:57:46ZengNature Publishing GroupNature Communications2041-17232017-02-01811810.1038/ncomms14265Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniationGyda Bjornsdottir0Stefania Benonisdottir1Gardar Sveinbjornsson2Unnur Styrkarsdottir3Gudmar Thorleifsson4G. Bragi Walters5Aron Bjornsson6Ingvar H. Olafsson7Elfar Ulfarsson8Arnor Vikingsson9Ragnheidur Hansdottir10Karl O. Karlsson11Thorunn Rafnar12Ingileif Jonsdottir13Michael L. Frigge14Augustine Kong15Asmundur Oddsson16Gisli Masson17Olafur T. Magnusson18Tomas Gudbjartsson19Hreinn Stefansson20Patrick Sulem21Daniel Gudbjartsson22Unnur Thorsteinsdottir23Thorgeir E. Thorgeirsson24Kari Stefansson25deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Department of Neurosurgery, Landspitali University HospitalDepartment of Neurosurgery, Landspitali University HospitalDepartment of Neurosurgery, Landspitali University HospitalDepartment of Medicine, Landspitali, National University HospitalDepartment of Dentistry, University of IcelandDepartment of Dentistry, University of IcelanddeCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Faculty of Medicine, University of IcelanddeCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.deCODE Genetics/Amgen, Inc.Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.https://doi.org/10.1038/ncomms14265 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson |
| spellingShingle |
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation Nature Communications |
| author_facet |
Gyda Bjornsdottir Stefania Benonisdottir Gardar Sveinbjornsson Unnur Styrkarsdottir Gudmar Thorleifsson G. Bragi Walters Aron Bjornsson Ingvar H. Olafsson Elfar Ulfarsson Arnor Vikingsson Ragnheidur Hansdottir Karl O. Karlsson Thorunn Rafnar Ingileif Jonsdottir Michael L. Frigge Augustine Kong Asmundur Oddsson Gisli Masson Olafur T. Magnusson Tomas Gudbjartsson Hreinn Stefansson Patrick Sulem Daniel Gudbjartsson Unnur Thorsteinsdottir Thorgeir E. Thorgeirsson Kari Stefansson |
| author_sort |
Gyda Bjornsdottir |
| title |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_short |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_full |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_fullStr |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_full_unstemmed |
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| title_sort |
sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-02-01 |
| description |
Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition. |
| url |
https://doi.org/10.1038/ncomms14265 |
| work_keys_str_mv |
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| _version_ |
1721451279476064256 |