VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.

Bibliographic Details
Main Authors: Steve Cornick, Manish Kumar, France Moreau, Herbert Gaisano, Kris Chadee
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11811-8
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spelling doaj-5efc315bfa514f489f437ae8d29afae42021-05-11T11:49:30ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11811-8VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasisSteve Cornick0Manish Kumar1France Moreau2Herbert Gaisano3Kris Chadee4Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryDepartments of Medicine and Physiology, University of TorontoDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of CalgaryVAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.https://doi.org/10.1038/s41467-019-11811-8
collection DOAJ
language English
format Article
sources DOAJ
author Steve Cornick
Manish Kumar
France Moreau
Herbert Gaisano
Kris Chadee
spellingShingle Steve Cornick
Manish Kumar
France Moreau
Herbert Gaisano
Kris Chadee
VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
Nature Communications
author_facet Steve Cornick
Manish Kumar
France Moreau
Herbert Gaisano
Kris Chadee
author_sort Steve Cornick
title VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_short VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_full VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_fullStr VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_full_unstemmed VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
title_sort vamp8-mediated muc2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description VAMP8 is a secretory pathway protein implicated in mucus secretion. Here the authors describe alterations in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8.
url https://doi.org/10.1038/s41467-019-11811-8
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AT francemoreau vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis
AT herbertgaisano vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis
AT krischadee vamp8mediatedmuc2mucinexocytosisfromcolonicgobletcellsmaintainsinnateintestinalhomeostasis
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