Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review
Abstract Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral d...
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doaj-5f00e5515aa840169474504ab5b550092020-11-25T00:27:36ZengBMCNutrition Journal1475-28912019-02-011811710.1186/s12937-019-0434-6Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic reviewReza Ganji0Meysam Moghbeli1Ramin Sadeghi2Golnaz Bayat3Azita Ganji4Department of Orthopedic surgery, North Khorasan University of Medical SciencesDepartment of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical SciencesNuclear Medicine Research Center, Mashhad University of Medical SciencesMedical Student, Student Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Mashhad University of Medical SciencesAbstract Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. The aim of our study was to systematically review the osteoporosis and osteopenia incidences among premenopausal females and males with CD. Methods This systematic review was done based on preferred reporting items for systematic reviews (PRISMA) guidelines. PubMed and Scopus and Cochran databases were searched according to the relevant medical subject headings (MeSH) of CD and bone mineral density until 2018. Prevalence of osteopenia and osteoporosis were used as effect size for meta-analysis. Cochrane Q (p < 0.05) and I2 index were presented to reveal the heterogeneity. Results 54 eligible full text reviews were included and nineteen selected for data extraction. Eleven articles didn’t have our inclusion criteria and had ignored confounding factors like age and menopause, and we excluded; data extraction was done in eight studies. A total of 563 premenopausal women and men who were from, UK, Brazil, India, Hungary, and Poland were included. The pooled prevalence of osteoporosis was 14.4% [95%CI: 9–20.5%] (Cochrane Q = 7.889, p = 0.96, I2 = 49.29%), and osteopenia was 39.6% [31.1–48.8%] (Cochrane Q = 14.24, p = 0.07, I2 = 71.92%), respectively. Conclusion Our findings suggest that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture. However, but results are pooled prevalence and we need more case –control studies with more sample size and consideration of confounding factors.http://link.springer.com/article/10.1186/s12937-019-0434-6Celiac diseaseOsteoporosisOsteopeniaBone mineral density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Reza Ganji Meysam Moghbeli Ramin Sadeghi Golnaz Bayat Azita Ganji |
spellingShingle |
Reza Ganji Meysam Moghbeli Ramin Sadeghi Golnaz Bayat Azita Ganji Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review Nutrition Journal Celiac disease Osteoporosis Osteopenia Bone mineral density |
author_facet |
Reza Ganji Meysam Moghbeli Ramin Sadeghi Golnaz Bayat Azita Ganji |
author_sort |
Reza Ganji |
title |
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
title_short |
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
title_full |
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
title_fullStr |
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
title_full_unstemmed |
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
title_sort |
prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review |
publisher |
BMC |
series |
Nutrition Journal |
issn |
1475-2891 |
publishDate |
2019-02-01 |
description |
Abstract Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. The aim of our study was to systematically review the osteoporosis and osteopenia incidences among premenopausal females and males with CD. Methods This systematic review was done based on preferred reporting items for systematic reviews (PRISMA) guidelines. PubMed and Scopus and Cochran databases were searched according to the relevant medical subject headings (MeSH) of CD and bone mineral density until 2018. Prevalence of osteopenia and osteoporosis were used as effect size for meta-analysis. Cochrane Q (p < 0.05) and I2 index were presented to reveal the heterogeneity. Results 54 eligible full text reviews were included and nineteen selected for data extraction. Eleven articles didn’t have our inclusion criteria and had ignored confounding factors like age and menopause, and we excluded; data extraction was done in eight studies. A total of 563 premenopausal women and men who were from, UK, Brazil, India, Hungary, and Poland were included. The pooled prevalence of osteoporosis was 14.4% [95%CI: 9–20.5%] (Cochrane Q = 7.889, p = 0.96, I2 = 49.29%), and osteopenia was 39.6% [31.1–48.8%] (Cochrane Q = 14.24, p = 0.07, I2 = 71.92%), respectively. Conclusion Our findings suggest that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture. However, but results are pooled prevalence and we need more case –control studies with more sample size and consideration of confounding factors. |
topic |
Celiac disease Osteoporosis Osteopenia Bone mineral density |
url |
http://link.springer.com/article/10.1186/s12937-019-0434-6 |
work_keys_str_mv |
AT rezaganji prevalenceofosteoporosisandosteopeniainmenandpremenopausalwomenwithceliacdiseaseasystematicreview AT meysammoghbeli prevalenceofosteoporosisandosteopeniainmenandpremenopausalwomenwithceliacdiseaseasystematicreview AT raminsadeghi prevalenceofosteoporosisandosteopeniainmenandpremenopausalwomenwithceliacdiseaseasystematicreview AT golnazbayat prevalenceofosteoporosisandosteopeniainmenandpremenopausalwomenwithceliacdiseaseasystematicreview AT azitaganji prevalenceofosteoporosisandosteopeniainmenandpremenopausalwomenwithceliacdiseaseasystematicreview |
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