Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes

Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes

Cyclic products can be obtained through the intramolecular version of the Nicholas reaction, which requires having the nucleophile connected to the alkyne unit. Here, we report the synthesis of 1-oxa-3-cyclooctynes starting from commercially available (1<i>R</i>,3<i>S</i>)-ca...

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Bibliographic Details
Main Authors: Diego M. Monzón, Juan Manuel Betancort, Tomás Martín, Miguel Ángel Ramírez, Víctor S. Martín, David Díaz Díaz
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
Nicholas reaction
cyclooctyne
propargylic carbocation
cyclization
oxacycle
ring strain
Online Access:https://www.mdpi.com/1420-3049/26/6/1629

Internet

https://www.mdpi.com/1420-3049/26/6/1629

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