Intramolecular Nicholas Reaction Enables the Stereoselective Synthesis of Strained Cyclooctynes
Cyclic products can be obtained through the intramolecular version of the Nicholas reaction, which requires having the nucleophile connected to the alkyne unit. Here, we report the synthesis of 1-oxa-3-cyclooctynes starting from commercially available (1<i>R</i>,3<i>S</i>)-ca...
Main Authors: | Diego M. Monzón, Juan Manuel Betancort, Tomás Martín, Miguel Ángel Ramírez, Víctor S. Martín, David Díaz Díaz |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/26/6/1629 |
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