MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

DNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A (MRE11A) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individ...

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Main Authors: Gilberto Vargas-Alarcón, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, José Manuel Fragoso, Guillermo Cardoso-Saldaña, Christian Vázquez-Vázquez, Julian Ramírez-Bello, Carlos Posadas-Romero, Rosalinda Posadas-Sánchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00530/full
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spelling doaj-5f04999f0d754254bf1efc7914f515bd2020-11-25T02:07:05ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-05-011010.3389/fgene.2019.00530444226MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican ProjectGilberto Vargas-Alarcón0Nonanzit Pérez-Hernández1José Manuel Rodríguez-Pérez2José Manuel Fragoso3Guillermo Cardoso-Saldaña4Christian Vázquez-Vázquez5Julian Ramírez-Bello6Carlos Posadas-Romero7Rosalinda Posadas-Sánchez8Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoResearch Unit on Endocrine and Metabolic Diseases, Hospital Juárez de México, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A (MRE11A) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Under different models, the rs13447720 (Odds ratio = 0.646, Padditive = 0.009; Odds ratio = 0.636, Pdominant = 0.012; Odds ratio = 0.664, Pover–dominant = 0.025; Odds ratio = 0.655, Pcodominant1 = 0.021) and rs499952 (Odds ratio = 0.807, Padditive = 0.032; Odds ratio = 0.643, Pcodominant2 = 0.034) polymorphisms were associated with a lower risk of subclinical atherosclerosis. On the other hand, the rs2155209 polymorphism was associated with a reduced risk of having a coronary artery calcification score ≥ 100 Agatston units. The rs13447720, rs499952, and rs2155209 polymorphisms, as well as the haplotypes that included the five studied polymorphisms were associated with some clinical and metabolic parameters in both subclinical atherosclerosis and healthy individuals. Our results suggest that the rs13447720 and rs499952 polymorphisms are associated with a decreased risk of developing subclinical atherosclerosis, whereas the rs2155209 is associated with a lower subclinical atherosclerosis severity (coronary artery calcification < 100 Agatston units). MRE11A polymorphisms and haplotypes were associated with clinical and metabolic parameters.https://www.frontiersin.org/article/10.3389/fgene.2019.00530/fullcardiovascular risk factorsDNA damagemeiotic recombination 11 homolog Apolymorphismssubclinical atherosclerosis
collection DOAJ
language English
format Article
sources DOAJ
author Gilberto Vargas-Alarcón
Nonanzit Pérez-Hernández
José Manuel Rodríguez-Pérez
José Manuel Fragoso
Guillermo Cardoso-Saldaña
Christian Vázquez-Vázquez
Julian Ramírez-Bello
Carlos Posadas-Romero
Rosalinda Posadas-Sánchez
spellingShingle Gilberto Vargas-Alarcón
Nonanzit Pérez-Hernández
José Manuel Rodríguez-Pérez
José Manuel Fragoso
Guillermo Cardoso-Saldaña
Christian Vázquez-Vázquez
Julian Ramírez-Bello
Carlos Posadas-Romero
Rosalinda Posadas-Sánchez
MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
Frontiers in Genetics
cardiovascular risk factors
DNA damage
meiotic recombination 11 homolog A
polymorphisms
subclinical atherosclerosis
author_facet Gilberto Vargas-Alarcón
Nonanzit Pérez-Hernández
José Manuel Rodríguez-Pérez
José Manuel Fragoso
Guillermo Cardoso-Saldaña
Christian Vázquez-Vázquez
Julian Ramírez-Bello
Carlos Posadas-Romero
Rosalinda Posadas-Sánchez
author_sort Gilberto Vargas-Alarcón
title MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
title_short MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
title_full MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
title_fullStr MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
title_full_unstemmed MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project
title_sort mre11a polymorphisms are associated with subclinical atherosclerosis and cardiovascular risk factors. a case-control study of the gea mexican project
publisher Frontiers Media S.A.
series Frontiers in Genetics
issn 1664-8021
publishDate 2019-05-01
description DNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A (MRE11A) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Under different models, the rs13447720 (Odds ratio = 0.646, Padditive = 0.009; Odds ratio = 0.636, Pdominant = 0.012; Odds ratio = 0.664, Pover–dominant = 0.025; Odds ratio = 0.655, Pcodominant1 = 0.021) and rs499952 (Odds ratio = 0.807, Padditive = 0.032; Odds ratio = 0.643, Pcodominant2 = 0.034) polymorphisms were associated with a lower risk of subclinical atherosclerosis. On the other hand, the rs2155209 polymorphism was associated with a reduced risk of having a coronary artery calcification score ≥ 100 Agatston units. The rs13447720, rs499952, and rs2155209 polymorphisms, as well as the haplotypes that included the five studied polymorphisms were associated with some clinical and metabolic parameters in both subclinical atherosclerosis and healthy individuals. Our results suggest that the rs13447720 and rs499952 polymorphisms are associated with a decreased risk of developing subclinical atherosclerosis, whereas the rs2155209 is associated with a lower subclinical atherosclerosis severity (coronary artery calcification < 100 Agatston units). MRE11A polymorphisms and haplotypes were associated with clinical and metabolic parameters.
topic cardiovascular risk factors
DNA damage
meiotic recombination 11 homolog A
polymorphisms
subclinical atherosclerosis
url https://www.frontiersin.org/article/10.3389/fgene.2019.00530/full
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