Nanoparticle Drug Delivery Systems for α-Mangostin

• Main Authors: Wathoni N, Rusdin A, Motoyama K, Joni IM, Lesmana R, Muchtaridi M
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-04-01
• Series: Nanotechnology, Science and Applications
• Subjects: garcinia mangostana; solubility; controlled release; targeted delivery; nanoparticle formulations; physicochemical properties
• Online Access: https://www.dovepress.com/nanoparticle-drug-delivery-systems-for-alpha-mangostin-peer-reviewed-article-NSA

Nasrul Wathoni,1 Agus Rusdin,1,2 Keiichi Motoyama,3 I Made Joni,4 Ronny Lesmana,5 Muchtaridi Muchtaridi6 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia; 2Department of Pharmacy, Faculty of Sports and Health, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia; 3Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; 4Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia; 5Department of Anatomy, Physiology and Biology Cell, Faculty of Medicine, Universitas Padjadjaran, Sumedang 45363, Indonesia; 6Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaCorrespondence: Muchtaridi MuchtaridiBandung-Sumedang KM 21, Sumedang, West Java 45363, IndonesiaTel [phone] 3510Fax [phone]Email [e-mail]: α-Mangostin, a xanthone derivative from the pericarp of Garcinia mangostana L., has numerous bioactivities and pharmacological properties. However, α-mangostin has low aqueous solubility and poor target selectivity in the human body. Recently, nanoparticle drug delivery systems have become an excellent technique to improve the physicochemical properties and effectiveness of drugs. Therefore, many efforts have been made to overcome the limitations of α-mangostin through nanoparticle formulations. Our review aimed to summarise and discuss the nanoparticle drug delivery systems for α-mangostin from published papers recorded in Scopus, PubMed and Google Scholar. We examined various types of nanoparticles for α-mangostin to enhance water solubility, provide controlled release and create targeted delivery systems. These forms include polymeric nanoparticles, nanomicelles, liposomes, solid lipid nanoparticles, nanofibers and nanoemulsions. Notably, nanomicelle modification increased α-mangostin solubility increased more than 10,000 fold. Additionally, polymeric nanoparticles provided targeted delivery and significantly enhanced the biodistribution of α-mangostin into specific organs. In conclusion, the nanoparticle drug delivery system could be a promising technique to increase the solubility, selectivity and efficacy of α-mangostin as a new drug candidate in clinical therapy.Keywords: Garcinia mangostana, solubility, controlled release, targeted delivery, nanoparticle formulations, physicochemical properties