Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used as an experimental model of Sporadic AD (SAD) in rodents and represents a promising tool for etiopatho...
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doaj-5f1211ee607f458aad1f9c540b3e0dbd2020-11-25T03:10:02ZengElsevierHeliyon2405-84402020-02-0162e03281Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's diseaseTiago Guardia de Souza e Silva0Maria Eliza Ferreira do Val de Paulo1Jeferson Rubens Mamona da Silva2Adilson da Silva Alves3Luiz Roberto G. Britto4Gilberto Fernando Xavier5Maria Regina Lopes Sandoval6Laboratory of Pharmacology, Butantan Institute, Avenida Vital Brasil, 1500, cep 05503-900, São Paulo, BrazilLaboratory of Pharmacology, Butantan Institute, Avenida Vital Brasil, 1500, cep 05503-900, São Paulo, BrazilLaboratory of Pharmacology, Butantan Institute, Avenida Vital Brasil, 1500, cep 05503-900, São Paulo, BrazilInstitute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 2415, São Paulo, BrazilInstitute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 2415, São Paulo, BrazilInstitute of Biosciences, University of São Paulo, Rua do Matão, Travessa 14, 101, São Paulo, BrazilLaboratory of Pharmacology, Butantan Institute, Avenida Vital Brasil, 1500, cep 05503-900, São Paulo, Brazil; Corresponding author.Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used as an experimental model of Sporadic AD (SAD) in rodents and represents a promising tool for etiopathogenic analysis and evaluation of new therapeutic proposals for AD. The icv-STZ model shows many aspects of SAD abnormalities, resulting in decreased brain glucose and energy metabolism, cognitive impairment, oxidative stress, neuronal loss, and amyloid angiopathy. Royal jelly (RJ), a substance produced by worker honeybees of the Apis mellifera species, has been popularly used for more than 30 years in areas related to health eating and natural medicine. Researches indicate that RJ has a several pharmacological activities, including neuroprotective and improvement of cognitive function. The objective of this study was to investigate the effects of oral treatment with royal jelly during 2 weeks in Wistar rats submitted to icv-STZ on a working memory and neuroprotection, as evaluated by neurogenesis, neurodegeneration and oxidative stress. In this study, icv-STZ injection induced deleterious effects in the hippocampus, associated with cognitive impairments, and developed marked neurodegeneration, besides the reduction of neurogenesis and increased oxidative stress. On the other hand, RJ long-term oral administration induced beneficial effects in animals injured by icv-STZ injection, increasing retention time for working spatial memory, reducing neurodegeneration and oxidative stress level and increasing the proliferation of new neurons in the hippocampus. Thus, RJ promotes beneficial effects on cognitive functions and exhibits a neuroprotective action in the STZ experimental model of SAD.http://www.sciencedirect.com/science/article/pii/S2405844020301262NeuroscienceCell biologyPharmaceutical scienceLearning and memoryNeuroprotectionOxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tiago Guardia de Souza e Silva Maria Eliza Ferreira do Val de Paulo Jeferson Rubens Mamona da Silva Adilson da Silva Alves Luiz Roberto G. Britto Gilberto Fernando Xavier Maria Regina Lopes Sandoval |
spellingShingle |
Tiago Guardia de Souza e Silva Maria Eliza Ferreira do Val de Paulo Jeferson Rubens Mamona da Silva Adilson da Silva Alves Luiz Roberto G. Britto Gilberto Fernando Xavier Maria Regina Lopes Sandoval Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease Heliyon Neuroscience Cell biology Pharmaceutical science Learning and memory Neuroprotection Oxidative stress |
author_facet |
Tiago Guardia de Souza e Silva Maria Eliza Ferreira do Val de Paulo Jeferson Rubens Mamona da Silva Adilson da Silva Alves Luiz Roberto G. Britto Gilberto Fernando Xavier Maria Regina Lopes Sandoval |
author_sort |
Tiago Guardia de Souza e Silva |
title |
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease |
title_short |
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease |
title_full |
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease |
title_fullStr |
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease |
title_full_unstemmed |
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease |
title_sort |
oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-stz rat model of sporadic alzheimer's disease |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2020-02-01 |
description |
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used as an experimental model of Sporadic AD (SAD) in rodents and represents a promising tool for etiopathogenic analysis and evaluation of new therapeutic proposals for AD. The icv-STZ model shows many aspects of SAD abnormalities, resulting in decreased brain glucose and energy metabolism, cognitive impairment, oxidative stress, neuronal loss, and amyloid angiopathy. Royal jelly (RJ), a substance produced by worker honeybees of the Apis mellifera species, has been popularly used for more than 30 years in areas related to health eating and natural medicine. Researches indicate that RJ has a several pharmacological activities, including neuroprotective and improvement of cognitive function. The objective of this study was to investigate the effects of oral treatment with royal jelly during 2 weeks in Wistar rats submitted to icv-STZ on a working memory and neuroprotection, as evaluated by neurogenesis, neurodegeneration and oxidative stress. In this study, icv-STZ injection induced deleterious effects in the hippocampus, associated with cognitive impairments, and developed marked neurodegeneration, besides the reduction of neurogenesis and increased oxidative stress. On the other hand, RJ long-term oral administration induced beneficial effects in animals injured by icv-STZ injection, increasing retention time for working spatial memory, reducing neurodegeneration and oxidative stress level and increasing the proliferation of new neurons in the hippocampus. Thus, RJ promotes beneficial effects on cognitive functions and exhibits a neuroprotective action in the STZ experimental model of SAD. |
topic |
Neuroscience Cell biology Pharmaceutical science Learning and memory Neuroprotection Oxidative stress |
url |
http://www.sciencedirect.com/science/article/pii/S2405844020301262 |
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