A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1

A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1

Transcription factors (TFs) play multiple roles in development. Given this multifunctionality, it has been assumed that TFs are evolutionarily highly constrained. Here, we investigate the molecular mechanisms for the origin of a derived functional interaction between two TFs, HOXA11 and FOXO1. We ha...

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Bibliographic Details
Main Authors: Mauris C. Nnamani, Soumya Ganguly, Eric M. Erkenbrack, Vincent J. Lynch, Laura S. Mizoue, Yingchun Tong, Heather L. Darling, Monika Fuxreiter, Jens Meiler, Günter P. Wagner
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305502

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