The Relationship Between Global Sleep Score And Inflammatory Markers In Obese Adults From The United States

• Main Authors: Huang Y, Jiang Y, Zhu M
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-11-01
• Series: Nature and Science of Sleep
• Subjects: global sleep score; inflammation; body mass index; perceived stress; obese adults
• Online Access: https://www.dovepress.com/the-relationship-between-global-sleep-score-and-inflammatory-markers-i-peer-reviewed-article-NSS

Ying Huang,1,* Ying Jiang,2,* Meilan Zhu2 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Rehabilitation, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meilan ZhuDepartment of Rehabilitation, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Donghu District, Nanchang, Jiangxi 330006, People’s Republic of ChinaEmail [e-mail]: Poor sleep is a risk factor for cardiovascular diseases (CVDs). The underlying pathogenesis is not clear. Levels of inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-ɑ (TNF-ɑ), have been found to be elevated in patients with CVDs.Aim: The study aimed to investigate the associations between sleep quality and serum inflammatory markers in a cohort of obese adults.Methods: This was a second analysis of the data from the Midlife in the United States (MIDUS) study, a longitudinal study of a national (US) sample of adults. A total of 1255 participants completed comprehensive biological assessments. The associations between global sleep score and serum levels of inflammatory markers were analyzed.Results: Univariate analysis showed that a higher global sleep score was correlated with lower age (r = −0.079, P= 0.009), higher BMI (r = 0.100, P= 0.001) and heavier perceived stress (r = 0.335, P<0.001). Multivariate linear regression analysis showed that the global sleep score was positively related to levels of IL-6 (Sβ=0.074, P=0.009), IL-8 (Sβ=0.089, P=0.002), TNF-ɑ (Sβ=0.0.082, P=0.005), E-selectin (Sβ=0.071, P=0.016) and intercellular adhesion molecule-1 (ICAM-1, Sβ=0.117, P<0.001) after adjustments were made for age, gender, race, marital status, education, current smoking status, physician-diagnosed CVDs and respiratory diseases, BMI and perceived stress. However, the global sleep score was not associated with serum IL-10 (Sβ=−0.021, P=0.463) and CRP (Sβ=0.035, P=0.059) levels after adjustments were made for these confounding factors.Conclusion: Poor sleep is positively associated with serum inflammatory marker levels among obese adults. Sufficient sleep may be particularly important for obese adults to prevent CVDs.Keywords: global sleep score, inflammation, body mass index, perceived stress, obese adults