Application of Radial Basis Function Network Tool for Correlation of CD4+ Count with Plasma Viral Load in HIV-Seropositive Individuals
Introduction: Human Immunodeficiency Virus (HIV) infects and cripples the immune system of the body. The two important marker CD4+T cells and Plasma viral load are crucial not only in understanding the disease progression but also in starting the antiretroviral therapy. A lot of research is goin...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-04-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7604/17745_CE(RA1)_F(T)_PF1(Ro_Om)_PFA(AK)_PF2(PAG).pdf |
Summary: | Introduction: Human Immunodeficiency Virus (HIV) infects and
cripples the immune system of the body. The two important
marker CD4+T cells and Plasma viral load are crucial not only
in understanding the disease progression but also in starting
the antiretroviral therapy. A lot of research is going on in
understanding the dynamic nature of HIV.
Aim: To find the correlation between CD4+ count and Plasma
Viral Load (PVL) measured by two different technologies;
with the help of correlation technique in conjunction with the
three dimensional HIV model with a purpose of establishing a
mathematical model between the CD4+ cells and PVL using
a sinusoidal function as well as Radial Basis Function (RBF)
neural network.
Materials and Methods: Plasma Viral Load were determined
by two different methods viz Exavir CavidiTM and Abbott Real
time HIV-1 assay and then they were correlated with the CD4+
count with the help of computational intelligence in predicting
viral load.
Results: It was found that there exists a positive correlation
between the CD4+ cells and viral loads. A correlation value of
0.4082 and 0.3652 was observed between CD4+ cells and viral
measured using Exavir CavidiTM and Abbott Real time HIV-1
assay respectively.
Conclusion: The existence of positive correlation had helped
us to understand the nature and dynamic of the existence of
HIV and how the CD4 + and PVL act. |
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ISSN: | 2249-782X 0973-709X |