Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice

Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice

Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockou...

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Bibliographic Details
Main Authors: Ana Paula M. S. Brandão, Fernanda S. Oliveira, Natalia B. Carvalho, Leda Q. Vieira, Vasco Azevedo, Gilson C. Macedo, Sergio C. Oliveira
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/589494

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