Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells

Abstract Background Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically devastating diseases affecting the pork industry globally. PRRS is caused by PRRS virus (PRRSV). Currently there are no effective treatments against this swine disease. Methods Through artificial...

Full description

Bibliographic Details
Main Authors:	Chang Huang, Denzil Bernard, Jiaqi Zhu, Radha Charan Dash, Alexander Chu, Alec Knupp, Anna Hakey, M. Kyle Hadden, Antonio Garmendia, Young Tang
Format:	Article
Language:	English
Published:	BMC 2020-07-01
Series:	Virology Journal
Subjects:	Porcine reproductive and respiratory syndrome (PRRS) PRRS viruses (PRRSV) CD163 Protein-protein interaction (PPI) Scavenger receptor cysteine-rich domain 5 (SRCR5) Bimolecular fluorescence complementation (BiFC)
Online Access:	http://link.springer.com/article/10.1186/s12985-020-01361-7

Similar Items

CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1
by: Piao Yu, et al.
Published: (2020-01-01)

Development of a Monoclonal Antibody Against Porcine CD163 SRCR5 Domain Which Partially Blocks Infection of PRRSV
by: Yujiao Zhang, et al.
Published: (2020-11-01)

Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro
by: Hongfang Ma, et al.
Published: (2021-06-01)

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection
by: Chunhe Guo, et al.
Published: (2019-08-01)

Molecular characterization of the major envelope protein of porcine reproductive and respiratory syndrome virus (PRRSV) and evaluation of its use for a diagnostic assay, vaccine development, and the examination of quasispecies evolution
by: Key, Kijona Farthing
Published: (2014)

Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)
by: Hu, Jianzhong
Published: (2014)

Identification of Differentially Expressed Non-coding RNA in Porcine Alveolar Macrophages from Tongcheng and Large White Pigs Responded to PRRSV
by: Yueran Zhen, et al.
Published: (2018-10-01)

In planta Protein Interactions of Three Alphacryptoviruses and Three Betacryptoviruses from White Clover, Red Clover and Dill by Bimolecular Fluorescence Complementation Analysis
by: Till Lesker, et al.
Published: (2013-10-01)

The spread of porcine reproductive and respiratory syndrome virus (PRRSV) by genotype and the association between genotype and clinical signs in Ontario, Canada 2004-2007
by: Rosendal, Thomas
Published: (2011)

Genetic resistance - an alternative for controlling PRRS?
by: Gerald Reiner
Published: (2016-11-01)

Lack of evidence of porcine reproductive and respiratory syndrome virus (PRRSV) infection in domestic swine in Brazil
by: Ciacci-Zanella Janice Reis, et al.
Published: (2004-01-01)

Initial vaccination and revaccination with Type I PRRS 94881 MLV reduces viral load and infection with porcine reproductive and respiratory syndrome virus
by: Jeremy Kroll, et al.
Published: (2018-08-01)

Low False-Positives in an mLumin-Based Bimolecular Fluorescence Complementation System with a Bicistronic Expression Vector
by: Shun Liu, et al.
Published: (2014-02-01)

Generation of murine macrophage-derived cell lines expressing porcine CD163 that support porcine reproductive and respiratory syndrome virus infection
by: Liangliang Li, et al.
Published: (2017-11-01)

Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory Syndrome Virus
by: Tong-Yun Wang, et al.
Published: (2021-06-01)

Interplay between Interferon-Mediated Innate Immunity and Porcine Reproductive and Respiratory Syndrome Virus
by: Mingyuan Han, et al.
Published: (2012-04-01)

Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization
by: Ana M. M. Stoian, et al.
Published: (2019-01-01)

Broad Protection of Pigs against Heterologous PRRSV Strains by a GP5-Mosaic DNA Vaccine Prime/GP5-Mosaic rVaccinia (VACV) Vaccine Boost
by: Junru Cui, et al.
Published: (2020-02-01)

Luminescence- and Fluorescence-Based Complementation Assays to Screen for GPCR Oligomerization: Current State of the Art
by: Elise Wouters, et al.
Published: (2019-06-01)

Current approaches towards quantitative mapping of the interactome
by: Alexander eBuntru, et al.
Published: (2016-05-01)

A Field Recombinant Strain Derived from Two Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-1) Modified Live Vaccines Shows Increased Viremia and Transmission in SPF Pigs
by: Julie Eclercy, et al.
Published: (2019-03-01)

Porcine reproductive and respiratory syndrome virus: web-based interactive tools to support surveillance and control initiatives
by: Marie-Ève Lambert, et al.
Published: (2019-03-01)

Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows
by: Sandra Genís, et al.
Published: (2020-09-01)

Macropinocytosis: New Insights Into Its Underappreciated Role in Innate Immune Cell Surveillance
by: Johnathan Canton
Published: (2018-10-01)

Reappraisal of PRRS Immune Control Strategies: The Way Forward
by: Massimo Amadori, et al.
Published: (2021-08-01)

Effect of compounds on the purification and antibody preparation of the extracellular domain fragment of the receptor CD163
by: Qi Wen-Bao, et al.
Published: (2011-03-01)

A Cautionary Note on the Use of Split-YFP/BiFC in Plant Protein-Protein Interaction Studies
by: Anneke Horstman, et al.
Published: (2014-05-01)

La pathogenèse du virus du syndrome reproducteur et respiratoire porcin (VSRRP) dans un nouveau modèle de cellules épithéliales des voies respiratoires du porc génétiquement modifiées (NPTr-CD163)
by: Köszegi, Marika
Published: (2019)

Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells
by: Gaopeng Hou, et al.
Published: (2019-08-01)

A Bimolecular Fluorescence Complementation Tool for Identification of Protein-Protein Interactions in Candida albicans
by: Ana Subotić, et al.
Published: (2017-10-01)

Application de la complémentation de fluorescence bi-moléculaire à l'étude du mode d'action des protéines Hox in vivo
by: Hudry, Bruno
Published: (2011)

Comparison of performances between three commercial ELISA kits for detection of antibodies against Porcine Reproductive and Respiratory Syndrome Virus (PPRSV) in swine sera samples
by: Zorana Zurovac Sapundžić, et al.
Published: (2020-12-01)

The immunosuppressive impact of PRRS virus on the immune response following anti - erysipelas vaccination in swine from various farms
by: Viorica Chiurciu, et al.
Published: (2014-12-01)

Ability of ELISAs to detect antibodies against porcine respiratory and reproductive syndrome virus in serum of pigs after inactivated vaccination and subsequent challenge
by: Sattler, Tatjana, et al.
Published: (2016)

Streptococcus suis and Porcine Reproductive and Respiratory Syndrome, Vietnam
by: Ngo Thi Hoa, et al.
Published: (2013-02-01)

Porcine Respiratory and Reproductive Syndrome Virus Variants, Vietnam and China, 2007
by: Qinghua Hu, et al.
Published: (2008-11-01)

Aptamer-Based QCM-Sensor for Rapid Detection of PRRS Virus
by: Chakpetch Kuitio, et al.
Published: (2018-11-01)

Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control
by: Chia-Ming Su, et al.
Published: (2021-04-01)

Immune Responses in Pigs Induced by Recombinant DNA Vaccine Co-Expressing Swine IL-18 and Membrane Protein of Porcine Reproductive and Respiratory Syndrome Virus
by: Zhuang Ding, et al.
Published: (2012-05-01)

Impact of alignment algorithm on the estimation of pairwise genetic similarity of porcine reproductive and respiratory syndrome virus (PRRSV)
by: Marie-Ève Lambert, et al.
Published: (2019-05-01)

Cannot write session to /tmp/vufind_sessions/sess_mm674amr51q0341cdn3qb1tkut