Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for ci...

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Bibliographic Details
Main Authors: Yebin Zhou, Bo Chen, Nanette Mittereder, Raghothama Chaerkady, Martin Strain, Ling-Ling An, Saifur Rahman, Wenting Ma, Choon Pei Low, Denice Chan, Frances Neal, Clifton O. Bingham, Kevon Sampson, Erika Darrah, Richard M. Siegel, Sarfaraz Hasni, Felipe Andrade, Katherine A. Vousden, Tomas Mustelin, Gary P. Sims
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
neutrophil
citrullination
PAD2
PAD4
rheumatoid arthritis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01200/full

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