Correlation between interleukin-6 and septic shock in children
Background Sepsis is a lifethreatening condition and the most common cause of death in intensive care units in developing countries, such as Indonesia. The first clinical signs of sepsis are usually nonspedfic. More specific signs and laboratory parameters often occur late and are associated '...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Indonesian Pediatric Society Publishing House
2012-12-01
|
Series: | Paediatrica Indonesiana |
Subjects: | |
Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/500 |
id |
doaj-5f402f6d644f4c5ba92a6691f67640b9 |
---|---|
record_format |
Article |
spelling |
doaj-5f402f6d644f4c5ba92a6691f67640b92020-11-25T01:29:35ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2012-12-01526352510.14238/pi52.6.2012.352-5385Correlation between interleukin-6 and septic shock in childrenStephanie Yulianto0Ari Runtunuwu1Vivekenanda Pateda2Jose Mandei3Julius Lolombulan4Department of Child Health, Sam Ratulangi University Medical School/Pro. Dr. R. D. Kandou Hospital, ManadoDepartment of Child Health, Sam Ratulangi University Medical School/Pro. Dr. R. D. Kandou Hospital, ManadoDepartment of Child Health, Sam Ratulangi University Medical School/Pro. Dr. R. D. Kandou Hospital, ManadoDepartment of Child Health, Sam Ratulangi University Medical School/Pro. Dr. R. D. Kandou Hospital, ManadoDepartment of Child Health, Sam Ratulangi University Medical School/Pro. Dr. R. D. Kandou Hospital, ManadoBackground Sepsis is a lifethreatening condition and the most common cause of death in intensive care units in developing countries, such as Indonesia. The first clinical signs of sepsis are usually nonspedfic. More specific signs and laboratory parameters often occur late and are associated 'With organ dysfunction and high mortality rates. Interleukin6 (IL--6) is a biomarker reported to be superior to clinical signs and conventional tests for sepsis. IL--6 levels may indicate microorganism invasion, as well as progression of infection into sepsis, severe sepsis, and septic shock. Objective To evaluate a correlation between interleukin (IL)6 and septic shock in children Methods This crosssectional study was conducted in the pediatric intensive care unit of Prof. Dr. R.D. Kandou Hospital, Manado, between June to September 2011. Subjects were children with sepsis or septic shock aged 1 month to 13 years, v.ith diagnoses based on the International Pediatric Sepsis Consensus Conference Criteria 2005. A onetime measurement of IL--6 plasma levels was done at the time of diagnosis. Data was analyzed by logistic regression test using SPSS version 17 software. A P value of <0.05 indicated statistical significance. Results The mean IL--6 plasma level in the septic group was 1.68 (95%CI 1.45 to 1.91) pg/mL and that of the septic shock group was 2.33 (95%CI 1.79 to 2.86) pg/mL. Our results showed a strong positive correlation between IL6 plasma levels v.ith the probability of septic shock in children v.ith sepsis (regression coefficient1.3lO, PO.024). Conclusion Higher plasma IL--6 levels were associated v.ith a higher risk of septic shock in children with sepsis. [Paediatr rndones.2012;52:352-5].https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/500sepsisinterleukin-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie Yulianto Ari Runtunuwu Vivekenanda Pateda Jose Mandei Julius Lolombulan |
spellingShingle |
Stephanie Yulianto Ari Runtunuwu Vivekenanda Pateda Jose Mandei Julius Lolombulan Correlation between interleukin-6 and septic shock in children Paediatrica Indonesiana sepsis interleukin-6 |
author_facet |
Stephanie Yulianto Ari Runtunuwu Vivekenanda Pateda Jose Mandei Julius Lolombulan |
author_sort |
Stephanie Yulianto |
title |
Correlation between interleukin-6 and septic shock in children |
title_short |
Correlation between interleukin-6 and septic shock in children |
title_full |
Correlation between interleukin-6 and septic shock in children |
title_fullStr |
Correlation between interleukin-6 and septic shock in children |
title_full_unstemmed |
Correlation between interleukin-6 and septic shock in children |
title_sort |
correlation between interleukin-6 and septic shock in children |
publisher |
Indonesian Pediatric Society Publishing House |
series |
Paediatrica Indonesiana |
issn |
0030-9311 2338-476X |
publishDate |
2012-12-01 |
description |
Background Sepsis is a lifethreatening condition and the most
common cause of death in intensive care units in developing
countries, such as Indonesia. The first clinical signs of sepsis are
usually nonspedfic. More specific signs and laboratory parameters
often occur late and are associated 'With organ dysfunction and
high mortality rates. Interleukin6 (IL--6) is a biomarker reported to
be superior to clinical signs and conventional tests for sepsis. IL--6
levels may indicate microorganism invasion, as well as progression
of infection into sepsis, severe sepsis, and septic shock.
Objective To evaluate a correlation between interleukin (IL)6
and septic shock in children
Methods This crosssectional study was conducted in the pediatric
intensive care unit of Prof. Dr. R.D. Kandou Hospital, Manado,
between June to September 2011. Subjects were children with
sepsis or septic shock aged 1 month to 13 years, v.ith diagnoses
based on the International Pediatric Sepsis Consensus Conference
Criteria 2005. A onetime measurement of IL--6 plasma levels
was done at the time of diagnosis. Data was analyzed by logistic
regression test using SPSS version 17 software. A P value of <0.05
indicated statistical significance.
Results The mean IL--6 plasma level in the septic group was 1.68
(95%CI 1.45 to 1.91) pg/mL and that of the septic shock group
was 2.33 (95%CI 1.79 to 2.86) pg/mL. Our results showed a
strong positive correlation between IL6 plasma levels v.ith the
probability of septic shock in children v.ith sepsis (regression
coefficient1.3lO, PO.024).
Conclusion Higher plasma IL--6 levels were associated v.ith a
higher risk of septic shock in children with sepsis. [Paediatr
rndones.2012;52:352-5]. |
topic |
sepsis interleukin-6 |
url |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/500 |
work_keys_str_mv |
AT stephanieyulianto correlationbetweeninterleukin6andsepticshockinchildren AT ariruntunuwu correlationbetweeninterleukin6andsepticshockinchildren AT vivekenandapateda correlationbetweeninterleukin6andsepticshockinchildren AT josemandei correlationbetweeninterleukin6andsepticshockinchildren AT juliuslolombulan correlationbetweeninterleukin6andsepticshockinchildren |
_version_ |
1725096198064308224 |