Mechanisms of Resistance to Conventional Therapies for Osteosarcoma
Osteosarcoma (OS) is the most common primary bone tumor, mainly occurring in children and adolescents. Current standard therapy includes tumor resection associated with multidrug chemotherapy. However, patient survival has not evolved for the past decades. Since the 1970s, the 5-year survival rate i...
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doaj-5f4147535f8a439794def08c8089c5772021-02-09T00:03:36ZengMDPI AGCancers2072-66942021-02-011368368310.3390/cancers13040683Mechanisms of Resistance to Conventional Therapies for OsteosarcomaLouise Marchandet0Morgane Lallier1Céline Charrier2Marc Baud’huin3Benjamin Ory4François Lamoureux5UMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceUMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceUMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceUMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceUMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceUMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, INSERM, Université de Nantes, 44035 Nantes, FranceOsteosarcoma (OS) is the most common primary bone tumor, mainly occurring in children and adolescents. Current standard therapy includes tumor resection associated with multidrug chemotherapy. However, patient survival has not evolved for the past decades. Since the 1970s, the 5-year survival rate is around 75% for patients with localized OS but dramatically drops to 20% for bad responders to chemotherapy or patients with metastases. Resistance is one of the biological processes at the origin of therapeutic failure. Therefore, it is necessary to better understand and decipher molecular mechanisms of resistance to conventional chemotherapy in order to develop new strategies and to adapt treatments for patients, thus improving the survival rate. This review will describe most of the molecular mechanisms involved in OS chemoresistance, such as a decrease in intracellular accumulation of drugs, inactivation of drugs, improved DNA repair, modulations of signaling pathways, resistance linked to autophagy, disruption in genes expression linked to the cell cycle, or even implication of the micro-environment. We will also give an overview of potential therapeutic strategies to circumvent resistance development.https://www.mdpi.com/2072-6694/13/4/683osteosarcomachemotherapy resistancechemotherapy circumvent |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Louise Marchandet Morgane Lallier Céline Charrier Marc Baud’huin Benjamin Ory François Lamoureux |
spellingShingle |
Louise Marchandet Morgane Lallier Céline Charrier Marc Baud’huin Benjamin Ory François Lamoureux Mechanisms of Resistance to Conventional Therapies for Osteosarcoma Cancers osteosarcoma chemotherapy resistance chemotherapy circumvent |
author_facet |
Louise Marchandet Morgane Lallier Céline Charrier Marc Baud’huin Benjamin Ory François Lamoureux |
author_sort |
Louise Marchandet |
title |
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma |
title_short |
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma |
title_full |
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma |
title_fullStr |
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma |
title_full_unstemmed |
Mechanisms of Resistance to Conventional Therapies for Osteosarcoma |
title_sort |
mechanisms of resistance to conventional therapies for osteosarcoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-02-01 |
description |
Osteosarcoma (OS) is the most common primary bone tumor, mainly occurring in children and adolescents. Current standard therapy includes tumor resection associated with multidrug chemotherapy. However, patient survival has not evolved for the past decades. Since the 1970s, the 5-year survival rate is around 75% for patients with localized OS but dramatically drops to 20% for bad responders to chemotherapy or patients with metastases. Resistance is one of the biological processes at the origin of therapeutic failure. Therefore, it is necessary to better understand and decipher molecular mechanisms of resistance to conventional chemotherapy in order to develop new strategies and to adapt treatments for patients, thus improving the survival rate. This review will describe most of the molecular mechanisms involved in OS chemoresistance, such as a decrease in intracellular accumulation of drugs, inactivation of drugs, improved DNA repair, modulations of signaling pathways, resistance linked to autophagy, disruption in genes expression linked to the cell cycle, or even implication of the micro-environment. We will also give an overview of potential therapeutic strategies to circumvent resistance development. |
topic |
osteosarcoma chemotherapy resistance chemotherapy circumvent |
url |
https://www.mdpi.com/2072-6694/13/4/683 |
work_keys_str_mv |
AT louisemarchandet mechanismsofresistancetoconventionaltherapiesforosteosarcoma AT morganelallier mechanismsofresistancetoconventionaltherapiesforosteosarcoma AT celinecharrier mechanismsofresistancetoconventionaltherapiesforosteosarcoma AT marcbaudhuin mechanismsofresistancetoconventionaltherapiesforosteosarcoma AT benjaminory mechanismsofresistancetoconventionaltherapiesforosteosarcoma AT francoislamoureux mechanismsofresistancetoconventionaltherapiesforosteosarcoma |
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