New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur.
Considering the undesirable attributes of synthetic fungicides and the availability of Ficus<em> </em>species in China, the stem of<em> Ficus tikoua </em>Bur. was investigated. One<strong> </strong>new antifungal pyr...
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doaj-5f4b34596dbd4320bbbca5a8fab31f342020-11-25T00:20:32ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-06-011367375738210.3390/ijms13067375New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur.Shaopeng WeiZhiqin JiWenjun WuConsidering the undesirable attributes of synthetic fungicides and the availability of Ficus<em> </em>species in China, the stem of<em> Ficus tikoua </em>Bur. was investigated. One<strong> </strong>new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (<strong>1</strong>), together with two known isoflavones, wighteone (<strong>2</strong>) and lupiwighteone (<strong>3</strong>) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MS<sup>n</sup> analyses. The antifungal activities of <strong>1</strong>–<strong>3</strong> against <em>Phytophthora infestans</em> were evaluated by direct spore germination assay, and the IC<sub>50</sub> values were 262.442, 198.153 and 90.365 µg·mL<sup>−1</sup>, respectively.http://www.mdpi.com/1422-0067/13/6/7375<em>Ficus tikoua </em>Bur.pyranoisoflavoneantifungal activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shaopeng Wei Zhiqin Ji Wenjun Wu |
spellingShingle |
Shaopeng Wei Zhiqin Ji Wenjun Wu New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. International Journal of Molecular Sciences <em>Ficus tikoua </em>Bur. pyranoisoflavone antifungal activity |
author_facet |
Shaopeng Wei Zhiqin Ji Wenjun Wu |
author_sort |
Shaopeng Wei |
title |
New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. |
title_short |
New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. |
title_full |
New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. |
title_fullStr |
New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. |
title_full_unstemmed |
New Antifungal Pyranoisoflavone from <em>Ficus tikoua </em>Bur. |
title_sort |
new antifungal pyranoisoflavone from <em>ficus tikoua </em>bur. |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2012-06-01 |
description |
Considering the undesirable attributes of synthetic fungicides and the availability of Ficus<em> </em>species in China, the stem of<em> Ficus tikoua </em>Bur. was investigated. One<strong> </strong>new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2",2"-dimethylpyrano (5",6":7,8) isoflavone (<strong>1</strong>), together with two known isoflavones, wighteone (<strong>2</strong>) and lupiwighteone (<strong>3</strong>) (with previously reported antifungal activities), were isolated from ethyl acetate extract by bioassay-guided fractionation. Their structures were determined by spectroscopic analysis, such as NMR (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, HMBC and NOESY), IR, UV and HRMS, as well as ESI-MS<sup>n</sup> analyses. The antifungal activities of <strong>1</strong>–<strong>3</strong> against <em>Phytophthora infestans</em> were evaluated by direct spore germination assay, and the IC<sub>50</sub> values were 262.442, 198.153 and 90.365 µg·mL<sup>−1</sup>, respectively. |
topic |
<em>Ficus tikoua </em>Bur. pyranoisoflavone antifungal activity |
url |
http://www.mdpi.com/1422-0067/13/6/7375 |
work_keys_str_mv |
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