Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation

Structural basis of SALM5-induced PTPδ dimerization for synaptic differentiation

Synaptic adhesion molecules mediate synaptic differentiation and formation. Here the authors present the structures of the synaptic adhesion molecule SALM5 alone and in complex with the LAR family receptor protein tyrosine phosphatase (LAR-RPTP) PTPδ, which reveals how SALM5 dimerization facilitates...

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Bibliographic Details
Main Authors: Zhaohan Lin, Jianmei Liu, Huandi Ding, Fei Xu, Heli Liu
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02414-2
Description
Summary:Synaptic adhesion molecules mediate synaptic differentiation and formation. Here the authors present the structures of the synaptic adhesion molecule SALM5 alone and in complex with the LAR family receptor protein tyrosine phosphatase (LAR-RPTP) PTPδ, which reveals how SALM5 dimerization facilitates higher-order signaling assembly of LAR-RPTPs.
ISSN:2041-1723

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