miR-155 as a Biomarker in B-Cell Malignancies
MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of se...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2016/9513037 |
id |
doaj-5f5c68005b2c4291a0661dae8326ad1a |
---|---|
record_format |
Article |
spelling |
doaj-5f5c68005b2c4291a0661dae8326ad1a2020-11-24T22:36:34ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/95130379513037miR-155 as a Biomarker in B-Cell MalignanciesHanne Due0Pernille Svendsen1Julie Støve Bødker2Alexander Schmitz3Martin Bøgsted4Hans Erik Johnsen5Tarec Christoffer El-Galaly6Anne Stidsholt Roug7Karen Dybkær8Department of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkDepartment of Haematology, Aarhus University Hospital, Tage-Hansens Gade 2, 8000 Aarhus C, DenmarkDepartment of Haematology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, DenmarkMicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malignancies using a systematic search strategy to identify relevant literature. miR-155 was upregulated in several malignancies compared to nonmalignant controls and overexpression of miR-155 was further associated with poor prognosis. Elevated expression of miR-155 shows potential as a diagnostic and prognostic biomarker in diffuse large B-cell lymphoma and chronic lymphocytic leukemia. Additionally, in vitro and in vivo studies suggest miR-155 as an efficient therapeutic target, supporting its oncogenic function. The use of inhibiting anti-miR structures indicates promising potential as novel anticancer therapeutics. Reports from 53 studies prove that miR-155 has the potential to be a molecular tool in personalized medicine.http://dx.doi.org/10.1155/2016/9513037 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanne Due Pernille Svendsen Julie Støve Bødker Alexander Schmitz Martin Bøgsted Hans Erik Johnsen Tarec Christoffer El-Galaly Anne Stidsholt Roug Karen Dybkær |
spellingShingle |
Hanne Due Pernille Svendsen Julie Støve Bødker Alexander Schmitz Martin Bøgsted Hans Erik Johnsen Tarec Christoffer El-Galaly Anne Stidsholt Roug Karen Dybkær miR-155 as a Biomarker in B-Cell Malignancies BioMed Research International |
author_facet |
Hanne Due Pernille Svendsen Julie Støve Bødker Alexander Schmitz Martin Bøgsted Hans Erik Johnsen Tarec Christoffer El-Galaly Anne Stidsholt Roug Karen Dybkær |
author_sort |
Hanne Due |
title |
miR-155 as a Biomarker in B-Cell Malignancies |
title_short |
miR-155 as a Biomarker in B-Cell Malignancies |
title_full |
miR-155 as a Biomarker in B-Cell Malignancies |
title_fullStr |
miR-155 as a Biomarker in B-Cell Malignancies |
title_full_unstemmed |
miR-155 as a Biomarker in B-Cell Malignancies |
title_sort |
mir-155 as a biomarker in b-cell malignancies |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
MicroRNAs have the potential to be useful biomarkers in the development of individualized treatment since they are easy to detect, are relatively stable during sample handling, and are important determinants of cellular processes controlling pathogenesis, progression, and response to treatment of several types of cancers including B-cell malignancies. miR-155 is an oncomiR with a crucial role in tumor initiation and development of several B-cell malignancies. The present review elucidates the potential of miR-155 as a diagnostic, prognostic, or predictive biomarker in B-cell malignancies using a systematic search strategy to identify relevant literature. miR-155 was upregulated in several malignancies compared to nonmalignant controls and overexpression of miR-155 was further associated with poor prognosis. Elevated expression of miR-155 shows potential as a diagnostic and prognostic biomarker in diffuse large B-cell lymphoma and chronic lymphocytic leukemia. Additionally, in vitro and in vivo studies suggest miR-155 as an efficient therapeutic target, supporting its oncogenic function. The use of inhibiting anti-miR structures indicates promising potential as novel anticancer therapeutics. Reports from 53 studies prove that miR-155 has the potential to be a molecular tool in personalized medicine. |
url |
http://dx.doi.org/10.1155/2016/9513037 |
work_keys_str_mv |
AT hannedue mir155asabiomarkerinbcellmalignancies AT pernillesvendsen mir155asabiomarkerinbcellmalignancies AT juliestøvebødker mir155asabiomarkerinbcellmalignancies AT alexanderschmitz mir155asabiomarkerinbcellmalignancies AT martinbøgsted mir155asabiomarkerinbcellmalignancies AT hanserikjohnsen mir155asabiomarkerinbcellmalignancies AT tarecchristofferelgalaly mir155asabiomarkerinbcellmalignancies AT annestidsholtroug mir155asabiomarkerinbcellmalignancies AT karendybkær mir155asabiomarkerinbcellmalignancies |
_version_ |
1725719497621372928 |