Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli

Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli

There are data to suggest that some ductal carcinoma in situ (DCIS) may evolve through an evolutionary bottleneck, where minor clones susceptible to the imposed selective pressure drive disease progression. Here, we tested the hypothesis that an impact of the inflammatory environment on DCIS evoluti...

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Bibliographic Details
Main Authors: Dominika Piasecka, Marcin Braun, Magdalena Mieszkowska, Lukasz Kowalczyk, Janusz Kopczynski, Radzislaw Kordek, Rafal Sadej, Hanna M. Romanska
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
DCIS
Inflammatory microenvironment
HER2
HIF1-α
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301494

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