Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men
Background and objectives Several studies have demonstrated that antisperm antibody (ASA) can interfere with fertilization. ASA can be detected in the serum or semen by different tests. In this study, the percentage of ASA-IgG was determined by the direct mixed antiglobulin reaction (MAR) test in...
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Qom University of Medical Sciences
2007-06-01
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doaj-5f773d7fb4054bb5a75aa8fec21624152021-03-27T08:43:45ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752007-06-01123945Antisperm Antibody and the Risk Factors of Its Formation in Infertile MenF Shahsavar0AR Kheirollahi1B Assadifar2MJ Tarrahi3 Iran University of Medical Sciences Lorestan University of Medical Sciences Iran University of Medical Sciences Lorestan University of Medical Sciences Background and objectives Several studies have demonstrated that antisperm antibody (ASA) can interfere with fertilization. ASA can be detected in the serum or semen by different tests. In this study, the percentage of ASA-IgG was determined by the direct mixed antiglobulin reaction (MAR) test in men from infertile couples in Khorramabad city. Furthermore, the risk factors of formation of ASA were evaluated to determine the correlation between these factors and presence of ASA. Methods 200 men were tested for ASA as a part of the infertility evaluation. Patients were grouped according to percentage of ASA of < 10% or ≥ 10%. Risk factors for ASA (varicocele, hernia, and genitourinary infections) were considered for each group. Statistical analysis was performed using Fisher’s exact test. Results ASA was detected in 18.5% of the studied cases. Prior varicocele was significantly associated with presence of ASA detected by direct MAR. Prior hernia was not associated with presence of ASA detected by direct MAR. Prior genitourinary infections were significantly associated with presence of ASA detected by direct MAR. Conclusion These findings suggest that manipulation of cord structures including vas deferens is not associated with formation of ASA; however, varicocele and prior genitourinary infections are significant risk factors for the development of ASA.http://journal.muq.ac.ir/article-1-479-en.htmlantisperm antibodyinfertilitymixed antiglobulin reaction |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
F Shahsavar AR Kheirollahi B Assadifar MJ Tarrahi |
spellingShingle |
F Shahsavar AR Kheirollahi B Assadifar MJ Tarrahi Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum antisperm antibody infertility mixed antiglobulin reaction |
author_facet |
F Shahsavar AR Kheirollahi B Assadifar MJ Tarrahi |
author_sort |
F Shahsavar |
title |
Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men |
title_short |
Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men |
title_full |
Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men |
title_fullStr |
Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men |
title_full_unstemmed |
Antisperm Antibody and the Risk Factors of Its Formation in Infertile Men |
title_sort |
antisperm antibody and the risk factors of its formation in infertile men |
publisher |
Qom University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
issn |
1735-7799 2008-1375 |
publishDate |
2007-06-01 |
description |
Background and objectives
Several studies have demonstrated that antisperm antibody (ASA) can interfere with fertilization. ASA can be detected in the serum or semen by different tests. In this study, the percentage of ASA-IgG was determined by the direct mixed antiglobulin reaction (MAR) test in men from infertile couples in Khorramabad city. Furthermore, the risk factors of formation of ASA were evaluated to determine the correlation between these factors and presence of ASA.
Methods
200 men were tested for ASA as a part of the infertility evaluation. Patients were grouped according to percentage of ASA of < 10% or ≥ 10%. Risk factors for ASA (varicocele, hernia, and genitourinary infections) were considered for each group. Statistical analysis was performed using Fisher’s exact test.
Results
ASA was detected in 18.5% of the studied cases. Prior varicocele was significantly associated with presence of ASA detected by direct MAR. Prior hernia was not associated with presence of ASA detected by direct MAR. Prior genitourinary infections were significantly associated with presence of ASA detected by direct MAR.
Conclusion
These findings suggest that manipulation of cord structures including vas deferens is not associated with formation of ASA; however, varicocele and prior genitourinary infections are significant risk factors for the development of ASA. |
topic |
antisperm antibody infertility mixed antiglobulin reaction |
url |
http://journal.muq.ac.ir/article-1-479-en.html |
work_keys_str_mv |
AT fshahsavar antispermantibodyandtheriskfactorsofitsformationininfertilemen AT arkheirollahi antispermantibodyandtheriskfactorsofitsformationininfertilemen AT bassadifar antispermantibodyandtheriskfactorsofitsformationininfertilemen AT mjtarrahi antispermantibodyandtheriskfactorsofitsformationininfertilemen |
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