Thymosin-β4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway

Thymosin-β4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway

Background/Aims: Hepatic stellate cells (HSCs) are the primary cell type responsible for liver fibrosis. Our study proved that thymosin beta 4 (Tβ4) has anti-fibrogenic effects in HSCs through PI3K/AKT pathway. However, the underlying mechanisms are not fully elucidated. Circular RNAs (circRNAs) pla...

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Bibliographic Details
Main Authors: Lili Zhu, Tingting Ren, Zixin Zhu, Mingliang  Cheng, Qiuju Mou, Mao Mu, Yongmei Liu, Yumei Yao, Yiju Cheng, Baofang Zhang, Zhuo Cheng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Liver fibrosis
Hepatic stellate cell
Thymosin β4
Circular RNA
MicroRNA
CeRNA
Online Access:https://www.karger.com/Article/FullText/495556

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