High rate of mutations in the BRCA1, BRCA2, CHEK2, NBN, and BLM genes in Russian ovarian cancer patients

High rate of mutations in the BRCA1, BRCA2, CHEK2, NBN, and BLM genes in Russian ovarian cancer patients

Background. The early diagnosis of ovarian cancer (OC) is an important problem in modern gynecological oncology due to significant detection rates for late-stage tumors. Intensive screening of patients from high-risk groups that include OC predisposition gene mutation carriers is indicated.Subjects...

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Bibliographic Details
Main Authors: Ye. I. Bateneva, M. G. Filippova, A. S. Tyulyandina, A. A. Meshcheryakov, K. I. Zhordania, A. N. Gritsai, V. V. Kadochnikova, D. D. Abramov, A. A. Ragimov, D. Yu. Trofimov, L. N. Lyubchenko
Format: Article
Language:Russian
Published: ABV-press 2015-01-01
Series:Opuholi Ženskoj Reproduktivnoj Sistemy
Subjects:
ovarian cancer
hereditary predisposition
mutation
brca1
brca2
chek
nbn
blm
polymerase chain reaction
molecular genetic diagnosis
founder effect
russian population
Online Access:https://ojrs.abvpress.ru/ojrs/article/view/410

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