Fe3O4@SiO2@ADMPT/H6P2W18O62: a novel Wells–Dawson heteropolyacid-based magnetic inorganic–organic nanohybrid material as potent Lewis acid catalyst for the efficient synthesis of 1,4-dihydopyridines

• Main Authors: Mohammad Ghanbari, Sanaz Moradi, Moslem Setoodehkhah
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2018-04-01
• Series: Green Chemistry Letters and Reviews
• Subjects: Wells–Dawson heteropolyacid; eco-friendly catalyst; 1,4-dihydopyridine; Hantzsch reaction; fe3O4 nanoparticles; green chemistry
• Online Access: http://dx.doi.org/10.1080/17518253.2018.1445781

A novel Wells–Dawson heteropolyacid-based magnetic Inorganic–organic nanohybrid, Fe3O4@SiO2@ADMPT/H6P2W18O62, was fabricated and used as a green, efficient, eco-friendly, and highly recyclable catalyst for the one-pot and multi-component synthesis of 1,4-Dihydopyridine (1,4-DHP) derivatives from the reaction of various aromatic aldehydes with ethyl acetoacetate and ammonium acetate with good to excellent yields and in a short span of time. The nanohybrid catalyst was prepared by the chemical anchoring of Wells–Dawson heteropolyacid H6P2W18O62 onto the surface of functionalized Fe3O4 nanoparticles with 2,4-bis(3,5-dimethylpyrazol)-triazine (ADMPT) linker. These nanocatalysts were identified by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and vibrating sample magnetometer (VSM). This protocol is developed as a safe, cost-effective and convenient alternate method for the synthesis of 1,4-DHP derivatives utilizing an eco-friendly, and a highly reusable catalyst.