Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease
Recently, the subthalamic nucleus (STN) has been shown to be critically involved in decision-making, action selection, and motor control. Here we investigate the effect of deep brain stimulation (DBS) of the STN on reward-based decision-learning in patients diagnosed with Parkinson’s disease (PD). W...
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doaj-5fa2ed13d1ac452b8fdf17578da3de862020-11-25T02:47:09ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612011-04-01510.3389/fnhum.2011.000307678Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s DiseaseNelleke Corine Van Wouwe0Nelleke Corine Van Wouwe1Scott A. Wylie2Wery P.M. Van Den Wildenberg3Guido P. H. Band4Adetoun A Abisogun5William J. Elias6Robert C. Frysinger7Richard K.R. Ridderinkhof8TNOLeiden University Institute of PsychologyUniversity of Virginia Health SystemsUniversity of AmsterdamLeiden University Institute of PsychologyUniversity of Virginia Health SystemsUniversity of Virginia Health SystemsUniversity of Virginia Health SystemsUniversity of AmsterdamRecently, the subthalamic nucleus (STN) has been shown to be critically involved in decision-making, action selection, and motor control. Here we investigate the effect of deep brain stimulation (DBS) of the STN on reward-based decision-learning in patients diagnosed with Parkinson’s disease (PD). We determined computational measures of outcome evaluation and reward prediction from PD patients who performed a probabilistic reward-based decision-learning task. In previous work, these measures covaried with activation in the nucleus caudatus (outcome evaluation during the early phases of learning) and the putamen (reward prediction during later phases of learning). We observed that stimulation of the STN motor regions in PD patients served to improve reward-based decision-learning, probably through its effect on activity in frontostriatal motor loops (prominently involving the putamen and, hence, reward prediction). In a subset of relatively younger patients with relatively shorter disease duration, the effects of DBS appeared to spread to more cognitive regions of the STN, benefitting loops that connect the caudate to various prefrontal areas important for outcome evaluation. These results highlight positive effects of STN stimulation on cognitive functions that may benefit PD patients in daily-life association-learning situations.http://journal.frontiersin.org/Journal/10.3389/fnhum.2011.00030/fullBasal GangliaDeep Brain StimulationSubthalamic NucleusParkinson’s diseaseprobabilistic learningreward-based decision-learning |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nelleke Corine Van Wouwe Nelleke Corine Van Wouwe Scott A. Wylie Wery P.M. Van Den Wildenberg Guido P. H. Band Adetoun A Abisogun William J. Elias Robert C. Frysinger Richard K.R. Ridderinkhof |
spellingShingle |
Nelleke Corine Van Wouwe Nelleke Corine Van Wouwe Scott A. Wylie Wery P.M. Van Den Wildenberg Guido P. H. Band Adetoun A Abisogun William J. Elias Robert C. Frysinger Richard K.R. Ridderinkhof Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease Frontiers in Human Neuroscience Basal Ganglia Deep Brain Stimulation Subthalamic Nucleus Parkinson’s disease probabilistic learning reward-based decision-learning |
author_facet |
Nelleke Corine Van Wouwe Nelleke Corine Van Wouwe Scott A. Wylie Wery P.M. Van Den Wildenberg Guido P. H. Band Adetoun A Abisogun William J. Elias Robert C. Frysinger Richard K.R. Ridderinkhof |
author_sort |
Nelleke Corine Van Wouwe |
title |
Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease |
title_short |
Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease |
title_full |
Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease |
title_fullStr |
Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease |
title_full_unstemmed |
Deep Brain Stimulation of the Subthalamic Nucleus improves Reward-based decision-learning in Parkinson’s Disease |
title_sort |
deep brain stimulation of the subthalamic nucleus improves reward-based decision-learning in parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2011-04-01 |
description |
Recently, the subthalamic nucleus (STN) has been shown to be critically involved in decision-making, action selection, and motor control. Here we investigate the effect of deep brain stimulation (DBS) of the STN on reward-based decision-learning in patients diagnosed with Parkinson’s disease (PD). We determined computational measures of outcome evaluation and reward prediction from PD patients who performed a probabilistic reward-based decision-learning task. In previous work, these measures covaried with activation in the nucleus caudatus (outcome evaluation during the early phases of learning) and the putamen (reward prediction during later phases of learning). We observed that stimulation of the STN motor regions in PD patients served to improve reward-based decision-learning, probably through its effect on activity in frontostriatal motor loops (prominently involving the putamen and, hence, reward prediction). In a subset of relatively younger patients with relatively shorter disease duration, the effects of DBS appeared to spread to more cognitive regions of the STN, benefitting loops that connect the caudate to various prefrontal areas important for outcome evaluation. These results highlight positive effects of STN stimulation on cognitive functions that may benefit PD patients in daily-life association-learning situations. |
topic |
Basal Ganglia Deep Brain Stimulation Subthalamic Nucleus Parkinson’s disease probabilistic learning reward-based decision-learning |
url |
http://journal.frontiersin.org/Journal/10.3389/fnhum.2011.00030/full |
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