Intramyocardial transplantation and tracking of human mesenchymal stem cells in a novel intra-uterine pre-immune fetal sheep myocardial infarction model: a proof of concept study.

Intramyocardial transplantation and tracking of human mesenchymal stem cells in a novel intra-uterine pre-immune fetal sheep myocardial infarction model: a proof of concept study.

Although stem-cell therapies have been suggested for cardiac-regeneration after myocardial-infarction (MI), key-questions regarding the in-vivo cell-fate remain unknown. While most available animal-models require immunosuppressive-therapy when applying human cells, the fetal-sheep being pre-immune u...

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Bibliographic Details
Main Authors: Maximilian Y Emmert, Benedikt Weber, Petra Wolint, Thomas Frauenfelder, Steffen M Zeisberger, Luc Behr, Sebastien Sammut, Jacques Scherman, Chad E Brokopp, Ruth Schwartländer, Viola Vogel, Peter Vogt, Jürg Grünenfelder, Hatem Alkadhi, Volkmar Falk, Andreas Boss, Simon P Hoerstrup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23533575/pdf/?tool=EBI

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