The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice
Prangos ferulacea has been used for GI disorders in traditional medicine. It has been known as an analgesic and anti-inflammatory herb among the communities. However, the analgesic effect of this plant has not been scientifically evaluated. Therefore, the aim of this study was to investigate the ana...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | fas |
Published: |
Jahrom University of Medical Sciences
2011-08-01
|
Series: | فصلنامه دانشگاه علوم پزشکی جهرم |
Subjects: | |
Online Access: | http://jmj.jums.ac.ir/article-1-63-en.html |
id |
doaj-5fbb4d6e16714e9d93fec02fd3cee43b |
---|---|
record_format |
Article |
spelling |
doaj-5fbb4d6e16714e9d93fec02fd3cee43b2020-11-25T03:36:02ZfasJahrom University of Medical Sciencesفصلنامه دانشگاه علوم پزشکی جهرم2008-79932008-84422011-08-019417The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in miceMasoumeh Emamghoreishi0Ali Taghavi1Katauon Javidnia2 Prangos ferulacea has been used for GI disorders in traditional medicine. It has been known as an analgesic and anti-inflammatory herb among the communities. However, the analgesic effect of this plant has not been scientifically evaluated. Therefore, the aim of this study was to investigate the analgesic effect of Prangos ferulacea in mice. Methods: 30 minutes after intraperitoneal administration of different doses of aqueous or methanolic extracts of Prangos ferulacea, its analgesic effect was evaluated in mice using formalin test. The durations of paw licking and biting were recorded at 5 min. intervals for 30 min. after injection of formalin. Results: The aqueous extract at the dose of 100mg/kg reduced pain at phase 2 and at doses of 300, 900 and 1350 mg/kg it reduced pain at phases 1 and 2 of formalin test. The methanolic extract reduced pain at the dose of 200mg/kg at phase 2, and at doses of 400 and 800 mg/kg at phases 1 and 2 of formalin test. Conclusion: The results of this study showed that the aqueous and methanolic extracts of Prangos ferulacea have analgesic properties. Both extracts contain compounds which exert both peripheral and central analgesia. Future studies are needed to isolate the effective compound and to find the analgesic mechanism of this plant.http://jmj.jums.ac.ir/article-1-63-en.htmlprangos ferulaceaanalgesicsformalin testplant extracts |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Masoumeh Emamghoreishi Ali Taghavi Katauon Javidnia |
spellingShingle |
Masoumeh Emamghoreishi Ali Taghavi Katauon Javidnia The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice فصلنامه دانشگاه علوم پزشکی جهرم prangos ferulacea analgesics formalin test plant extracts |
author_facet |
Masoumeh Emamghoreishi Ali Taghavi Katauon Javidnia |
author_sort |
Masoumeh Emamghoreishi |
title |
The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice |
title_short |
The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice |
title_full |
The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice |
title_fullStr |
The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice |
title_full_unstemmed |
The effect of aqueous and methanolic extracts of Prangos ferulacea on formalin-induced pain in mice |
title_sort |
effect of aqueous and methanolic extracts of prangos ferulacea on formalin-induced pain in mice |
publisher |
Jahrom University of Medical Sciences |
series |
فصلنامه دانشگاه علوم پزشکی جهرم |
issn |
2008-7993 2008-8442 |
publishDate |
2011-08-01 |
description |
Prangos ferulacea has been used for GI disorders in traditional medicine. It has been known as an analgesic and anti-inflammatory herb among the communities. However, the analgesic effect of this plant has not been scientifically evaluated. Therefore, the aim of this study was to investigate the analgesic effect of Prangos ferulacea in mice. Methods: 30 minutes after intraperitoneal administration of different doses of aqueous or methanolic extracts of Prangos ferulacea, its analgesic effect was evaluated in mice using formalin test. The durations of paw licking and biting were recorded at 5 min. intervals for 30 min. after injection of formalin. Results: The aqueous extract at the dose of 100mg/kg reduced pain at phase 2 and at doses of 300, 900 and 1350 mg/kg it reduced pain at phases 1 and 2 of formalin test. The methanolic extract reduced pain at the dose of 200mg/kg at phase 2, and at doses of 400 and 800 mg/kg at phases 1 and 2 of formalin test. Conclusion: The results of this study showed that the aqueous and methanolic extracts of Prangos ferulacea have analgesic properties. Both extracts contain compounds which exert both peripheral and central analgesia. Future studies are needed to isolate the effective compound and to find the analgesic mechanism of this plant. |
topic |
prangos ferulacea analgesics formalin test plant extracts |
url |
http://jmj.jums.ac.ir/article-1-63-en.html |
work_keys_str_mv |
AT masoumehemamghoreishi theeffectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice AT alitaghavi theeffectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice AT katauonjavidnia theeffectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice AT masoumehemamghoreishi effectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice AT alitaghavi effectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice AT katauonjavidnia effectofaqueousandmethanolicextractsofprangosferulaceaonformalininducedpaininmice |
_version_ |
1724551765994504192 |