LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.
Bibliographic Details
Main Authors: |
Xin-Jiang Lu,
Qiang Chen,
Ye-Jing Rong,
Guan-Jun Yang,
Chang-Hong Li,
Ning-Yi Xu,
Chao-Hui Yu,
Hui-Ying Wang,
Shun Zhang,
Yu-Hong Shi,
Jiong Chen |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-09-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/ncomms12719
|