New somatic BRAF splicing mutation in Langerhans cell histiocytosis

New somatic BRAF splicing mutation in Langerhans cell histiocytosis

Abstract Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF V600 and MAP2K1 mutations by whole exome sequencing. We identified a new somatic BRAF splicing...

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Bibliographic Details
Main Authors: Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G. Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E. Allen, Jean Donadieu, Jean-François Emile
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Cancer
Subjects:
Langerhans cell histiocytosis
BRAF
Splicing mutation
Targeted therapy
Online Access:http://link.springer.com/article/10.1186/s12943-017-0690-z

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