The role of mitochondria-derived peptides in cardiovascular disease: Recent updates
Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cy...
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2019-09-01
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doaj-5fec3023bd3c4b3285ccde827a1a490e2021-05-20T07:38:20ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-09-01117The role of mitochondria-derived peptides in cardiovascular disease: Recent updatesYingxi Yang0Huijuan Gao1Huan Zhou2Qi Liu3Zhongwen Qi4Ying Zhang5Junping Zhang6First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaTianjin University of Traditional Chinese Medicine, 312 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaDepartment of Traditional Chinese Medicine, Affiliated Hospital of Nankai University, 4 Wei Shan Road, He Xi District, Tianjin 300222, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaDepartment of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China; Corresponding author at: Department of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, China.Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD.http://www.sciencedirect.com/science/article/pii/S0753332219315781Cardiovascular diseaseMitochondria-derived peptidesHumaninMOTS-c |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yingxi Yang Huijuan Gao Huan Zhou Qi Liu Zhongwen Qi Ying Zhang Junping Zhang |
spellingShingle |
Yingxi Yang Huijuan Gao Huan Zhou Qi Liu Zhongwen Qi Ying Zhang Junping Zhang The role of mitochondria-derived peptides in cardiovascular disease: Recent updates Biomedicine & Pharmacotherapy Cardiovascular disease Mitochondria-derived peptides Humanin MOTS-c |
author_facet |
Yingxi Yang Huijuan Gao Huan Zhou Qi Liu Zhongwen Qi Ying Zhang Junping Zhang |
author_sort |
Yingxi Yang |
title |
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
title_short |
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
title_full |
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
title_fullStr |
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
title_full_unstemmed |
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates |
title_sort |
role of mitochondria-derived peptides in cardiovascular disease: recent updates |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-09-01 |
description |
Mitochondria-derived peptides (MDPs) are a series of peptides encoded by mitochondrial DNA, and have similar functions to mitochondria. At present there are three types of MDPs that have been found, including Humanin, MOTS-c and SHLP1-6. They are new metabolic regulators of human body, and play a cytoprotective role in maintaining mitochondrial function and cell viability under pressure. Increasingly researchers have demonstrated that MDPs have proved effects on cell survival, metabolism, response to stressors, and inflammation in vivo and vitro. Recently with the advance of research, it have shown that MDPs have significant effects on the development of cardiovascular diseases (CVD). In this review, we will cover the relationships of MDPs with cardiovascular risk factors, myocardial ischemia, reperfusion injury, myocardial fibrosis, and coronary microcirculatory dysfunction, and also their possible pathogenic mechanisms. MDPs are considered to be novel biomarkers or therapeutic targets for CVD. |
topic |
Cardiovascular disease Mitochondria-derived peptides Humanin MOTS-c |
url |
http://www.sciencedirect.com/science/article/pii/S0753332219315781 |
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