Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience
Abstract Background Pulmonary disorders and respiratory failure represent one of the most common morbidities of preterm newborns admitted to neonatal intensive care units (NICUs). The use of nasal high-flow therapy (nHFT) has been more recently introduced into the NICUs as a non-invasive respiratory...
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doaj-5ff9324037c54ea7914422d9651401cf2020-11-25T02:01:38ZengBMCItalian Journal of Pediatrics1824-72882017-12-014311810.1186/s13052-017-0438-9Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experienceAntonio Di Mauro0Manuela Capozza1Sergio Cotugno2Silvio Tafuri3Francesco Paolo Bianchi4Federico Schettini5Raffaella Panza6Nicola Laforgia7Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariNeonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariNeonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariSection of Hygiene, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariSection of Hygiene, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariNeonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariNeonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariNeonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of BariAbstract Background Pulmonary disorders and respiratory failure represent one of the most common morbidities of preterm newborns admitted to neonatal intensive care units (NICUs). The use of nasal high-flow therapy (nHFT) has been more recently introduced into the NICUs as a non-invasive respiratory (NIV) support. Methods We performed a retrospective study to evaluate safety and effectiveness of nHFT as primary support for infants born < 29 weeks of gestation and/or VLBW presenting with mild Respiratory Distress Syndrome (RDS). The main outcome was the percentage of patients that did not need mechanical ventilation. Secondary outcomes were rate of bronchopulmonary dysplasia (BDP), air leaks, nasal injury, late onset sepsis (LOS), intraventricular hemorrhage (IVH), retinopathy (ROP), necrotizing enterocolitis (NEC), hemodynamically-significant patent ductus arteriosus (PDA) and death. Results Sixty-four preterm newborns were enrolled. Overall, 93% of enrolled patients did not need mechanical ventilation. In a subgroup analysis, 88.5% of infants < 29 weeks and 86.7% of infants ELBW (< 1000 g BW) did not need mechanical ventilation. BPD was diagnosed in 26.6% of preterms enrolled (Mild 20%, Moderate 4.5%, Severe 1.5%). In subgroup analysis, BPD was diagnosed in 53.9% of newborns with GA < 29 weeks, in 53.3% of ELBW newborns and in 11.1% of small for gestational age (SGA) newborns. Neither air leaks nor nasal injury were recorded as well as no exitus occurred. LOS, IVH, ROP, NEC and PDA occurred respectively in 16.1%, 0%, 7.8%, and 1.6% of newborns. Conclusions According to our results, n-HFT seems to be effective as first respiratory support in preterm newborns with mild RDS. Further studies in a larger number of preterm newborns are required to confirm nHFT effectiveness in the acute phase of RDS.http://link.springer.com/article/10.1186/s13052-017-0438-9Nasal high flow therapyVery low birth weight infantsNeonatal respiratory distress syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio Di Mauro Manuela Capozza Sergio Cotugno Silvio Tafuri Francesco Paolo Bianchi Federico Schettini Raffaella Panza Nicola Laforgia |
spellingShingle |
Antonio Di Mauro Manuela Capozza Sergio Cotugno Silvio Tafuri Francesco Paolo Bianchi Federico Schettini Raffaella Panza Nicola Laforgia Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience Italian Journal of Pediatrics Nasal high flow therapy Very low birth weight infants Neonatal respiratory distress syndrome |
author_facet |
Antonio Di Mauro Manuela Capozza Sergio Cotugno Silvio Tafuri Francesco Paolo Bianchi Federico Schettini Raffaella Panza Nicola Laforgia |
author_sort |
Antonio Di Mauro |
title |
Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
title_short |
Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
title_full |
Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
title_fullStr |
Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
title_full_unstemmed |
Nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
title_sort |
nasal high flow therapy in very low birth weight infants with mild respiratory distress syndrome: a single center experience |
publisher |
BMC |
series |
Italian Journal of Pediatrics |
issn |
1824-7288 |
publishDate |
2017-12-01 |
description |
Abstract Background Pulmonary disorders and respiratory failure represent one of the most common morbidities of preterm newborns admitted to neonatal intensive care units (NICUs). The use of nasal high-flow therapy (nHFT) has been more recently introduced into the NICUs as a non-invasive respiratory (NIV) support. Methods We performed a retrospective study to evaluate safety and effectiveness of nHFT as primary support for infants born < 29 weeks of gestation and/or VLBW presenting with mild Respiratory Distress Syndrome (RDS). The main outcome was the percentage of patients that did not need mechanical ventilation. Secondary outcomes were rate of bronchopulmonary dysplasia (BDP), air leaks, nasal injury, late onset sepsis (LOS), intraventricular hemorrhage (IVH), retinopathy (ROP), necrotizing enterocolitis (NEC), hemodynamically-significant patent ductus arteriosus (PDA) and death. Results Sixty-four preterm newborns were enrolled. Overall, 93% of enrolled patients did not need mechanical ventilation. In a subgroup analysis, 88.5% of infants < 29 weeks and 86.7% of infants ELBW (< 1000 g BW) did not need mechanical ventilation. BPD was diagnosed in 26.6% of preterms enrolled (Mild 20%, Moderate 4.5%, Severe 1.5%). In subgroup analysis, BPD was diagnosed in 53.9% of newborns with GA < 29 weeks, in 53.3% of ELBW newborns and in 11.1% of small for gestational age (SGA) newborns. Neither air leaks nor nasal injury were recorded as well as no exitus occurred. LOS, IVH, ROP, NEC and PDA occurred respectively in 16.1%, 0%, 7.8%, and 1.6% of newborns. Conclusions According to our results, n-HFT seems to be effective as first respiratory support in preterm newborns with mild RDS. Further studies in a larger number of preterm newborns are required to confirm nHFT effectiveness in the acute phase of RDS. |
topic |
Nasal high flow therapy Very low birth weight infants Neonatal respiratory distress syndrome |
url |
http://link.springer.com/article/10.1186/s13052-017-0438-9 |
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