Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor

• Main Authors: Dasom Shin, Won Choi, Hyunsu Bae
• Format: Article
• Language: English
• Published: MDPI AG 2018-04-01
• Series: Toxins
• Subjects: atopic dermatitis (AD); house dust mite extract (DFE); 2,4-dinitrochlorobenzene (DNCB); bee venom phospholipase A2 (bvPLA2); skin inflammation; CD206; mannose receptor
• Online Access: http://www.mdpi.com/2072-6651/10/4/146

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206.