Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house d...
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doaj-5ffec42210d6489a844bffcb910d91e32020-11-24T22:08:55ZengMDPI AGToxins2072-66512018-04-0110414610.3390/toxins10040146toxins10040146Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose ReceptorDasom Shin0Won Choi1Hyunsu Bae2Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaDepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaDepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, KoreaAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206.http://www.mdpi.com/2072-6651/10/4/146atopic dermatitis (AD)house dust mite extract (DFE)2,4-dinitrochlorobenzene (DNCB)bee venom phospholipase A2 (bvPLA2)skin inflammationCD206mannose receptor |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dasom Shin Won Choi Hyunsu Bae |
spellingShingle |
Dasom Shin Won Choi Hyunsu Bae Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor Toxins atopic dermatitis (AD) house dust mite extract (DFE) 2,4-dinitrochlorobenzene (DNCB) bee venom phospholipase A2 (bvPLA2) skin inflammation CD206 mannose receptor |
author_facet |
Dasom Shin Won Choi Hyunsu Bae |
author_sort |
Dasom Shin |
title |
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
title_short |
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
title_full |
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
title_fullStr |
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
title_full_unstemmed |
Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor |
title_sort |
bee venom phospholipase a2 alleviate house dust mite-induced atopic dermatitis-like skin lesions by the cd206 mannose receptor |
publisher |
MDPI AG |
series |
Toxins |
issn |
2072-6651 |
publishDate |
2018-04-01 |
description |
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206. |
topic |
atopic dermatitis (AD) house dust mite extract (DFE) 2,4-dinitrochlorobenzene (DNCB) bee venom phospholipase A2 (bvPLA2) skin inflammation CD206 mannose receptor |
url |
http://www.mdpi.com/2072-6651/10/4/146 |
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