Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations

Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations

Pb is a potential risk factor for cognition, mainly mediated by enhanced oxidative stress. Resveratrol, a natural polyphenol with crucial anti-oxidative property, is recently implicated in preventing cognitive deficits in normal aging and neurodegenerative disorders. Its beneficial effects have been...

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Bibliographic Details
Main Authors: Lijie Zhang, Runqi Tu, Yawei Wang, Yazhen Hu, Xing Li, Xuemin Cheng, Yanyan Yin, Wenjie Li, Hui Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Physiology
Subjects:
lead (Pb)
cognition
sirtuin 1(SIRT1)
oxidative stress
β-amyloid (Aβ)
brain derived neuronal factor (BDNF)
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00446/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00446/full

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