Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy
Objective. This paper systematically assessed the efficacy and safety of Jingtong granule (JG) for cervical radiculopathy (CR). Methods. Randomized controlled trials comparing JG with no intervention, placebo, or conventional therapies were retrieved. The trials testing JG combined with conventional...
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doaj-601fea74da734c03a9bb59be1700fa1b2020-11-25T00:55:03ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/158453158453Jingtong Granule: A Chinese Patent Medicine for Cervical RadiculopathyLiguo Zhu0Jinghua Gao1Jie Yu2Minshan Feng3Jinyu Li4Shangquan Wang5Xu Wei6Department of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaDepartment of Spine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaDepartment of Orthopaedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang Street, Dongcheng District, Beijing 100700, ChinaDepartment of General Orthopedics, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaDepartment of Scientific Research, Wangjing Hospital, China Academy of Chinese Medical Sciences, Huajiadi Street, Chaoyang District, Beijing 100102, ChinaObjective. This paper systematically assessed the efficacy and safety of Jingtong granule (JG) for cervical radiculopathy (CR). Methods. Randomized controlled trials comparing JG with no intervention, placebo, or conventional therapies were retrieved. The trials testing JG combined with conventional therapies versus conventional therapies were also enrolled. Study selection, methodological assessment, data extraction, and analysis were conducted in accordance with the Cochrane standards. The strength of evidence was evaluated according to GRADE approach. Results. Three trials with 400 participants were included. Methodological quality was evaluated as generally low. One study found that JG showed significant difference on decreasing pain scores compared with placebo. Meta-analysis indicated that JG plus conventional analgesic exhibited a significant immediate effect on the pain scores (WMD = 1.63; 95% CI: 1.29 to 1.98; P<0.00001). Additionally, JG combined with analgesic presented beneficial immediate effect on neck disability index. However, the treatment effects of JG demonstrated in the trials were not large, and the safety of JG was unproven. Finally the evidence level was evaluated to be low. Conclusions. Our results indicated that JG showed some potential benefits for CR. Nevertheless, treatment effects are uncertain due to both the methodological concerns and the very modest reported improvements.http://dx.doi.org/10.1155/2015/158453 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liguo Zhu Jinghua Gao Jie Yu Minshan Feng Jinyu Li Shangquan Wang Xu Wei |
spellingShingle |
Liguo Zhu Jinghua Gao Jie Yu Minshan Feng Jinyu Li Shangquan Wang Xu Wei Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy Evidence-Based Complementary and Alternative Medicine |
author_facet |
Liguo Zhu Jinghua Gao Jie Yu Minshan Feng Jinyu Li Shangquan Wang Xu Wei |
author_sort |
Liguo Zhu |
title |
Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy |
title_short |
Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy |
title_full |
Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy |
title_fullStr |
Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy |
title_full_unstemmed |
Jingtong Granule: A Chinese Patent Medicine for Cervical Radiculopathy |
title_sort |
jingtong granule: a chinese patent medicine for cervical radiculopathy |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
Objective. This paper systematically assessed the efficacy and safety of Jingtong granule (JG) for cervical radiculopathy (CR). Methods. Randomized controlled trials comparing JG with no intervention, placebo, or conventional therapies were retrieved. The trials testing JG combined with conventional therapies versus conventional therapies were also enrolled. Study selection, methodological assessment, data extraction, and analysis were conducted in accordance with the Cochrane standards. The strength of evidence was evaluated according to GRADE approach. Results. Three trials with 400 participants were included. Methodological quality was evaluated as generally low. One study found that JG showed significant difference on decreasing pain scores compared with placebo. Meta-analysis indicated that JG plus conventional analgesic exhibited a significant immediate effect on the pain scores (WMD = 1.63; 95% CI: 1.29 to 1.98; P<0.00001). Additionally, JG combined with analgesic presented beneficial immediate effect on neck disability index. However, the treatment effects of JG demonstrated in the trials were not large, and the safety of JG was unproven. Finally the evidence level was evaluated to be low. Conclusions. Our results indicated that JG showed some potential benefits for CR. Nevertheless, treatment effects are uncertain due to both the methodological concerns and the very modest reported improvements. |
url |
http://dx.doi.org/10.1155/2015/158453 |
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